Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2006-10-31
2006-10-31
Helms, Larry R. (Department: 1643)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S388220, C530S388800, C530S389700, C530S391100, C530S391700, C530S391900, C424S135100, C424S078310, C424S192100, C424S194100, C435S320100, C435S328000, C536S023400, C536S023500, C536S024200, C536S024100
Reexamination Certificate
active
07129330
ABSTRACT:
The present invention relates to multivalent Fvantibody construct having at least four variable domains which are linked with each over via the peptide linkers 1, 2 and 3. The invention also concerns expression plasmids which code for such an Fvantibody construct and a method of producing the Fvantibody constructs as well as their use.
REFERENCES:
patent: 5534254 (1996-07-01), Huston et al.
patent: 5635599 (1997-06-01), Pastan et al.
patent: 5837242 (1998-11-01), Holliger et al.
patent: 5856456 (1999-01-01), Whitlow et al.
patent: 5892020 (1999-04-01), Mezes et al.
patent: 6759518 (2004-07-01), Kontermann et al.
patent: 2005/0004352 (2005-01-01), Kontermann et al.
patent: 0 952 218 (1999-10-01), None
Gruber et al Journal of Immunology 1994, 152:5368-5374.
Csoka et al (Leukemia, 1996. 10:1765-1772).
Gruber et al., 1994, “Efficient tumor cell lysis mediated by a bispecific single chain antibody expressed inEscherichia coli”, Journal of Immunology 10:5368-5374.
Mack et al., 1995, “A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity”, Proceedings of the National Academy of Sciences of the United States of America 92:7021-7025.
Kurucz et al., 1995, “Retargeting f CTL by an efficiently refolded bispecific single-chain Fv dimer produced in bacteria”, Journal of Immunology 154:4576-4582.
De Jonge et al., 1995, “Production and characterization of bispecific single-chain antibody fragments”, Molecular Immunology 32:1405-1412.
Coloma et al., “Design and production of novel tetravel bispecific antibodies”, Nature Biotechnology 15:159-163.
Kipriyanov et al., 1999, “Bispecific tandem diabody for tumor therapy with improved antigen binding and pharmacokinetics”, Journal of Molecular Biology 293:41-56.
Kipriyanov et al, 1996, J-Immunol. Meth. 196:51-62.
Kipriyanov et al., 1997, Protein Eng. 10:445-453.
Kipriyanov Sergej
Little Melvyn
Deutsches Krebsforschungszentrum Stiftung des Offentlichen Recht
Helms Larry R.
Tungaturthi Parithosh K.
Wilson Sonsini Goodrich & Rosati
LandOfFree
Multivalent antibody constructs does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Multivalent antibody constructs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Multivalent antibody constructs will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3646731