Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1994-09-19
1996-04-30
Walsh, Stephen G.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
530350, 530839, 930120, C07K 14475, C07K 1448, C07K 1900
Patent
active
055126618
ABSTRACT:
The present invention relates to chimeric neurotrophic factors which comprise at least a portion of a naturally occurring cellular factor and a portion of at least one other molecule such that the resulting chimeric molecule has neurotrophic activity. It is based, in part, on the discovery that chimeric molecules comprising portions of both NGF and BDNF are likely to possess neurotrotrophic activity, and in some cases exhibit a spectrum of activity larger than that of either parent molecule. It is further based on the discovery that chimeric molecules comprising neurotrophic factor sequences as well as additional peptide sequences may retain neurotrophic activity, and in some cases may exhibit a more potent activity than the parent factor. The chimeric neurotrophic factor molecules of the invention provide a number of advantages relative to naturally occurring neurotrophic factors. Chimeric neurotrophic factors may be used to provide, for example, the activity of two neurotrophic factors in a single molecule, or may serve as superagonists of an endogenous neurotrophic factor, thereby enabling an increased biological response at lower doses.
REFERENCES:
patent: 4855406 (1989-08-01), Yanaihara et al.
patent: 5134121 (1992-07-01), Mobley et al.
patent: 5180820 (1993-01-01), Barde et al.
Lindsay et al., Devel. Biol. 112: 319-328 (1985).
Johnson et al., J. Neurosci. 6(10):3031-3038 (1986).
Lindsay, J. Neurosci. 8(7):2394-2405 (1988).
Ibanez et al., EMBO J. 9(5):1477-1483 (1990).
Scott et al., Nature 302: 538-540 (1983).
Ullrich et al., Nature 303: 821-825 (1983).
Hohn et al., Nature 344: 339-341 (1990).
Kanaya et al., Gene 83: 65-74 (1989).
Schulz et al., Principles of Protein Structure, pp. 14-16 (1979).
Leibrock et al., Nature 341: 149-152, 14 Sep. 1989.
Bernard et al., EMBO J.2: 2375-2383, 1983.
Maison Pierre et al., Science 247: 1446-1451, 23 Mar. 1990.
Furth Mark E.
Ip Nancy P.
Lindsay Ronald M.
Shooter Eric M.
Squinto Stephen P.
Kempler Gail M.
Regeneron Pharmaceuticals Inc.
Walsh Stephen G.
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