Multisubstituted 1-hydroxy-9-acridones with anticancer activity

Details Multisubstituted 1-hydroxy-9-acridones with anticancer activity Multisubstituted 1-hydroxy-9-acridones with anticancer activity

1991-03-18

1994-03-22

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

562433, 568630, C07C 6342

Patent

active

052966020

ABSTRACT:
The present invention provides a compound having the structure: ##STR1## The present invention also provides a method for synthesizing a compound having the above-identified structure as well as the intermediate compounds produced according to that method. The present invention further provides a pharmaceutical composition comprising the above compounds. Lastly, the present invention provides a method of inhibiting growth of tumor cells.

REFERENCES:
patent: 4691059 (1987-09-01), Mita et al.
Su, T. L., et al., Tetrahedron Letters, vol. 32, No. 12, pp. 1541-1544 (Mar. 18, 1991).
Chou, T. C., et al., Preclin. Pharm./Exper. Therapeutics, vol. 32, p. 403, abstract No. 2395 (Mar. 1991).
Chou, T. C., et al., Preclin. Pharm./Exper. Therapeutics, vol. 30, p. 608, abstract No. 2422, (Mar. 1989).
Chou, T. C., et al., Phytotherapy Research, vol. 3, pp. 237-242 (1989).

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