Multistep process for the physical depolymerization of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C536S021000, C536S124000

Reexamination Certificate

active

07939512

ABSTRACT:
The present invention is directed to a multistep process for the physical depolymerization of heparin wherein heparin is subjected to at least two γ-ray irradiations and wherein between two irradiation steps the depolymerised heparin is subjected to a separation step and only a fraction of the depolymerised heparin obtained from the first irradiation is subjected to the second irradiation step. It is also directed to heparin-derived oligosaccharide fractions obtainable by the process of the invention.

REFERENCES:
patent: 4788307 (1988-11-01), Lormeau et al.
patent: 4987222 (1991-01-01), De Ambrosi et al.
patent: 6075013 (2000-06-01), Weitz et al.
patent: 7091337 (2006-08-01), De Ambrosi et al.
patent: 0269937 (1988-06-01), None
patent: WO0069444 (2000-11-01), None
patent: WO 03/076474 (2003-09-01), None
Bisio et al, Carbohydrate Polymers, 2004, 55, 101-112.
International Search Report, Apr. 13, 2005.

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