Multistage process for the preparation of highly pure...

Details Multistage process for the preparation of highly pure... Multistage process for the preparation of highly pure...

2005-02-22

2005-02-22

Lilling, Herbert J. (Department: 1651)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing nitrogen-containing organic compound

C435S128000, C435S243000, C435S247000, C562S114000, C562S623000, C560S159000

Reexamination Certificate

active

06858414

ABSTRACT:
The present invention provides a purification process whereby deferoxamine B produced by a microorganism and in mixture with other polyhydroxamates produced by the microorganism may be converted into its mesylate salt substantially free of the other polyhydroxamates and substantially free of chloride ion. The process includes adsorption and desorption of the deferoxamine B on an adsorption resin, direct precipitation of the deferoxamine free base out of the eluent from the adsorption resin, contacting of the deferoxamine B free base with methanesulfonic acid and isolation of the deferoxamine B mesylate salt by precipitation. This process minimizes decomposition of deferoxamine B.

REFERENCES:
patent: 3118823 (1964-01-01), Gaeumann et al.
patent: 3153621 (1964-10-01), Gaeumann et al.
patent: 3247197 (1966-04-01), Gaeumann et al.
patent: 4987253 (1991-01-01), Bergeron
patent: 5254724 (1993-10-01), Bergeron et al.
patent: 5322961 (1994-06-01), Bergeron, Jr.
patent: 5364965 (1994-11-01), Bergeron, Jr.
patent: 5367113 (1994-11-01), Bergeron, Jr.
patent: 5374771 (1994-12-01), Koyari et al.
patent: 5430176 (1995-07-01), Wuts
patent: 5493053 (1996-02-01), Bergeron, Jr.
patent: 0 347 163 (1989-12-01), None
patent: WO 9303045 (1993-02-01), None
patent: 9309088 (1993-05-01), None
Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9thEd. (1996) “Deferoxamine”, pp. 1668-1669, The McGraw-Hill Companies.
Physicians' Desk Reference, 53rdEd. (1999) “Desferal®”, pp. 2010-2011, Medical Economics Company, Inc.
Bickel, H. et al., “Stoffwechselprodukte von Actinomyceten” Helvetica Chimica Acta, vol. XLIII, No. 261, (1960) pp. 2129-2138.
The United States Pharmacopeia/The National Formulary USP24/NF19 (1999), “Deferoxaminc Mesylate” pp. 499-200, United States Pharmacopeial Convention, Inc.
The United States Pharmacopeia/The National Formulary USP24/NF19 (1999), “<221> Chloride and Sulfate” pp. 1857-1858, United States Pharmacopeial Convention, Inc.
The United States Pharmacopeia/The National Formulary USP24/NF19 (1999), “<921> Water Determination” pp. 2003-2004, United States Pharmacopeial Convention, Inc.

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