Multispecific chimeric receptors

Details Multispecific chimeric receptors Multispecific chimeric receptors

1995-05-30

2000-08-15

Caputa, Anthony C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435 697, 4353201, 530350, 5303873, 536 234, C12N 1562, C07K 14705

Patent

active

061035211

ABSTRACT:
Novel multispecific chimeric receptor DNA sequences, expression cassettes and vectors containing these sequences as well as cells containing the chimeric DNA and novel chimeric receptor proteins expressed from the sequences are provided in the present invention. The novel multispecific chimeric receptor DNA and amino acid sequences comprise at least three domains that do not naturally exist together: (1) a multispecific binding domain comprising at least two extracellular inducer-responsive clustering domains which serves to bind at least one specific inducer molecule, (2) a transmembrane domain, which crosses the plasma membrane, and (3) either a proliferation signaling domain that signals the cell to divide, or an effector function signaling domain which directs a host cell to perform its specialized function. Optionally, all the multispecific chimeric receptors may contain one or more intracellular inducer-responsive clustering domains attached to one or more of the cytoplasmic signaling domains or the transmembrane domain. The present invention also relates to novel hybrid multispecific chimeric receptors comprising at least one proliferation signaling domain and at least one effector function signaling domain together on the multispecific receptor molecule. The present invention further relates to therapeutic methods and strategies that employ the cells expressing these novel chimeric receptors for the treatment of cancer, infectious disease and autoimmune disease which may have greater therapeutic benefit over a combination of drug therapies.

REFERENCES:
patent: 5260203 (1993-11-01), Ladner et al.
patent: 5336603 (1994-08-01), Capon et al.
patent: 5359046 (1994-10-01), Capon et al.
patent: 5741899 (1998-04-01), Capon et al.
Bird et al., J.Biol.Chem. 265:19151-19157, (1990).
Caruso, Mol.Med.Today 2:181-223, (1996).
Coghlan, New Scientist, Nov., (1995).
Culver et al., TIG 10:174-178, (1994).
Stein et al., Cell Biol. 14:3392-3402, (1994).
Gorny et al., J.Virol. 66:7538-7542, (1992).
Gorochov et al., Int.J.Cancer 7:53-57, (1992).
Gross et al., Proc.Natl.Acad.Sci. 86:10024-10028, (1989).
Gunzburg et al., Mol.Med.Today pp. 410-417, (1995).
Heinzel et al., J.Virol. 62:3738-3746, (1988).
Olshevsky et al., J.Virol. 64:5701-5707, (1990).
Hoffman-LaRoche, Curr.Opin.Ther.Pat. 12:2049, (1992).
Marshall, Science p. 1751, (1995).
Mastrangelo et al., Seminars in Oncology 23:4-21, (1996).
Sodroski et al., Nature 322:470-474, (1986).
Spencer et al. (1993) 262,1019-1024.
Eshar et al., "Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the .gamma. or .zeta. subunits of the immunoglobulin and T-cell receptors", Proc. Natl. Acad. Sci., USA, 90:720-724, (1993).
Kishimoto et al., "Cytokine Signal Transduction", Cell, 76:253-262, (1994).
Kolanus et al., "T Cell Activation by Clustered Tyrosine Kinases", Cell, 74:171-183, (1993).
Miyazaki et al., "Functional Activation of Jak1 and Jak3 by Selective Association with IL-2 Receptor Subunits", Science, 266:1045-1047, (1994).
Roberts et al., "Targeting of Human Immunodeficiency Virus-Infected Cells by CD28.sup.+ T Lymphocytes Armed With Universal T-Cell Receptors", Blood, 84(9):2878-2889, (1994).
Sato et al., "Multimeric cytokine receptors: common versus specific functions", Current Opinion in Cell Biology, 6:174-179, (1994).
Schlessinger et al., "Growth Factor Signaling by Receptor Tyrosine Kinases", Neuron, 9:383-391, (1992).
Stahl et al., "The Alphas, Betas, and Kinases of Cytokine Receptor Complexes", Cell, 74:587-590, (1993).
Ullrich et al., "Signal Transduction by Receptors with Tyrosine Kinase Activity", Cell,61:203-212, (1990).
Weiss et al., "T Cell Antigen Receptor Signal Transduction: A Tale of Tails and Cytoplasmic Protein-Tyrosine Kinases", Cell, 73:209-212, (1993).
Wilks et al., "Two Novel Protein-Tyrosine Kinases, Each with a Second Phosphotransferase-Related Catalytic Domain, Define a New Class of Protein Kinase", Molecular and Cellular Biology, 11(4):2057-2065, (1991).
Witthuhn et al., "JAK2 Associates with the Erythropoietin Receptor and Is Tyrosine Phosphorylated and Activated following Stimulation with Erythropoietin", Cell, 74:227-236, (1993).

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