Multispecific antigenic proteins

Details Multispecific antigenic proteins Multispecific antigenic proteins

1995-06-07

1999-10-26

Duffy, Patricia A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 691, 435 693, 435 711, 435 712, 435 914, 435 9142, 43525233, 4353201, 435471, 935 25, C12P 2104

Patent

active

059726598

ABSTRACT:
A novel conjugated protein produced by recombinant DNA techniques comprises a low molecular weight carrier protein portion that is normally self-aggregating to an immunogenic higher molecular weight proteinaceous material and a hapten portion wich is a peptide fraction that contains an epitope for an antigen for a pathogenic disease attached to the low molecular weight carrier portion. On aggregation of the self-aggregating protein, the hapten is on the surface of the viral particle, allowing for recognition of the hapten by the immune system. Upon introduction in vivo, the viral protein produces antibodies to both the self-aggregating protein and the hapten. A plurality of the conjugated proteins having different haptens can be combined into a viral protein to provide multi specific vacicines conferring immunity to a variety of pathogenic agents.

REFERENCES:
patent: 4722840 (1988-02-01), Valenzu et al.
patent: 5316931 (1994-05-01), Donson et al.
Maramorosch et al, Methods in Virology, vol. VII, Academic Press, N.Y. N.Y., 1984. pp. 265-266.
Collmer et al. Virology 126:449-458, 198.
Valenzuela et al (1982) Nature 298:347-50.
Boujes-Bocquet et al (1984) Md. Approaches Vaccine, ed. Chonoch et al Cold Spring Harbor, Abst.
Emini et al (1984) Virology 137:74-85.

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