Multipotent lymphohematopoietic progenitor cells

Details Multipotent lymphohematopoietic progenitor cells Multipotent lymphohematopoietic progenitor cells

2006-09-14

2011-10-11

Barnhart Driscoll, Lora E (Department: 1653)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S375000, C435S377000

Reexamination Certificate

active

08034613

ABSTRACT:
This invention relates to hematopoietic precursors derived from human embryonic stem cells. In the culture of differentiated cells from human ES cells, the fully committed hematopoietic precursors are CD34+ and CD43+ but not CD45+. If the cells are cultured until they express CD45, then the cells lose the ability to produce differentiated cells of the lymphoid lineages.

REFERENCES:
patent: 5759793 (1998-06-01), Schwartz et al.
patent: 6018096 (2000-01-01), Keating et al.
patent: 6280718 (2001-08-01), Kaufman et al.
patent: 7615374 (2009-11-01), Slukvin et al.
patent: 2002/0019047 (2002-02-01), Waldmann et al.
patent: 2002/0131962 (2002-09-01), Waldmann et al.
patent: 2006/0063255 (2006-03-01), Lebkowski et al.
patent: 2006/0275901 (2006-12-01), Slukvin et al.
patent: 2007/0072295 (2007-03-01), Slukvin et al.
patent: 2008/0233610 (2008-09-01), Thomson et al.
patent: 2009/0081784 (2009-03-01), Slukvin et al.
patent: 2003-108677 (2003-04-01), None
patent: 531979 (2009-09-01), None
patent: 01/36589 (2001-05-01), None
patent: 01/51616 (2001-07-01), None
patent: 2006/022330 (2006-03-01), None
patent: 2006/130651 (2006-12-01), None
patent: 2006130651 (2006-12-01), None
patent: 2007095064 (2007-08-01), None
patent: 2008118820 (2008-10-01), None
Akashi K et al. 2000. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404: 193-197.
“Help:About.” Accessed online at www.wikipedia.com May 7, 2010. 1 page.
Martin CH et al. 2008. Differences in lymphocyte developmental potential between human embryonic stem cell and umbilical cord blood—derived hematopoietic progenitor cells. Blood 112: 2730-2737.
Dahlke M, et al., “The biology of CD45 and its use as a therapeutic target,” Leuk. Lymphoma 45:229-236 (2004).
Kaufman D, et al., “Hematopoietic colony-forming cells derived from human embryonic stem cells,” Proc. Natl. Acad. Sci. USA 98:10716-10721 (2001).
Nakano T, et al., “Generation of lymphohematopoietic cells from embryonic stem cells in culture,” Science 265:1098-1101 (1994).
Remold-O'Donnell E, et al., “Expression on blood cells of sialophorin, the surface glycoprotein that is defective in Wiskott-Aldrich syndrome,” Blood 70:104-109 (1987).
Vodyanik M, et al., “Human embryonic stem cell-derived CD34+ cells: efficient production in the coculture with OP9 stromal cells and analysis of lymphohematopoietic potential,” Blood, 105:617-626 (2005).
Vodyanik M, et al., “Leukosialin (CD43) defines hematopoietic progenitors in human embryonic stem cell differentiation cultures,” Blood 108:2095-2105 (2006).
Gong, et al., “Fusions of Human Ovarian Carcinoma Cells with Autologous or Allogeneic Dendritic Cells Induce Antitumor Immunity,” J. Immun., 165:1705-1711 (2000).
Habibian, et al., “The Fluctuating Phenotype of the Lymphohematopoietic Stem Cell with Cell Cycle Transit”, J. Exp. Med. 188:393-398 (1998).
Martinez, et al., “Characterization of a common precursor population for dendritic cells”, Nature, 415(6875): 1043-1047 (2002).
Odorico, et al., “Multilineage Differentiation from Human Embryonic Stem Cell Lines,” Stem cells 19:193-204 (2001 ).
Parkhurst, et al., “Hybrids of dendritic cells and tumor cells generated by electrofusion simultaneously present immunodominant epitopes from multiple human tumor-associated antigens in the context of MHC class I and class II molecules”, J. Immunology 170:5317-5325 (2003).
Ryu, et al., “In Vitro Generation of Functional Dendritic Cells from Human Umbilical Cord Blood CD34+ Cells by a 2-Step Culture Method” International Journal of Hematology, 80(3):281-286 (2004).
Scot-Taylor, “Human tumour and dendritic cell hybrids generated by electrofusion: potential for cancer vaccines”, Biochemica et Biophysica Acta; 2000; p. 265-279; Elsevier Science B.V.
Senju, et al., “Generation and genetic modification of dendritic cells derived from mouse embryonic stem cells”, Blood, 101(9):3501-3508 (2003).
Shamblott, et al., “Human embryonic germ cell derivatives express a broad range of developmentally distinct markers and proliferate extensively in vitro,” Proc. Natl. Acad. Sci. U.S.A. 98:113-118 (2001).
Slukvin, et al., “Development of Lymphohematopoietic Progenitors during Human Embryonic Stem (hES) Cell Differentiation on OP9 Stromal Cells.” Blood, 104(11): 763A (2004).
Slukvin, et al., “Directed Differentiation of Human Embryonic Stem Cells into Functional Dendritic Cells through the Myeloid Pathway”, Journal of Immunology, 176(5):2924-2932 (2006).
Szabolcs, et al., “Expansion of Immunostimulatory Denritic cells Among the Myeloid Progeny of Human CD34+ Bone Marrow Precursors Cultured with c-kit Ligand, Granulocyte-Macrophage Colony-Stimulating Factor, and TNF-alpha”, Journal of Immunology, 154(112): 5851-5861 (1995).
Thomson, et al., “Embryonic Stem Cell Lines Derived from Human Blastocysts”, J. Science, 1998, 282:1145-1147.
Zhan, et al., “Functional antigen-presenting leucocytes derived from human embryonic stem cells in vitro”, Lancet 364:163-171 (2004).
Swedish Patent Application No. 0702695-8 Office action dated Oct. 8, 2008.
Swedish Patent Application No. 0702695-8 response to the Oct. 8, 2008 Office action.
European Patent Application No. 06771688.6 Office action dated Feb. 19, 2009.
European Patent Application No. 06771688.6 response to the Feb. 19, 2009 Office action.
Great Britain Patent Application No. 0723152.5 Office action dated Sep. 22, 2009.
Singapore Patent Application No. 200718257-9 Office action dated Jan. 19, 2010.
Great Britain Patent Application No. 0816154.9 Office action dated Oct. 1, 2008.
Great Britain Patent Application No. 0816154.9 response to the Oct. 1, 2008 Office action.
Great Britain Patent Application No. 0816154.9 Office action dated Oct. 30, 2009.
U.S. Appl. No. 11/443,608 Office action dated Sep. 22, 2008.
U.S. Appl. No. 11/443,608 response to the Sep. 22, 2008 Office action.
U.S. Appl. No. 11/443,608 Office action dated Apr. 17, 2009.
U.S. Appl. No. 11/443,608 response to the Apr. 17, 2009 Office action.
U.S. Appl. No. 11/443,608 Office action dated Oct. 16, 2009.
U.S. Appl. No. 11/443,608 response to the Oct. 16, 2009 Office action.
U.S. Appl. No. 11/672,724 Office action dated May 15, 2009.
U.S. Appl. No. 11/672,724 response to the May 15, 2009 Office action.
U.S. Appl. No. 11/672,724 Office action dated Dec. 17, 2009.
U.S. Appl. No. 12/024,770 Office action dated Dec. 15, 2008.
U.S. Appl. No. 12/024,770 response to the Dec. 15, 2008 Office action.
Great Britain Patent Application No. 0723152.5 response, dated Mar. 19, 2010, to Office action.
Ginis I, et al., “Differences between human and mouse embryonic stem cells,” Dev. Biol. 269:360-380 (2004).
Xu R, et al., “Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ESCs,” Nat. Methods 2:185-190 (2005).
Odorico J, et al., “Multilineage differentiation from human embryonic stem cell lines,” Stem Cells 19: 193-204 (2001).
Daheron L, et al., “LIFISTAT3 signaling fails to maintain self-renewal of human embryonic stem cells,” Stem Cells 22:770-778 (2004).
Xu R, et al., “BMP4 initiates human embryonic stem cell differentiation to trophoblast,” Nat. Biotechnol. 20: 1261-1264 (2002).
Li F, et al., “Bone morphogenetic protein 4 induces efficient hematopoietic differentiation of rhesus monkey embryonic stem cells in vitro”, Blood 98:335-342 (2001).
Li F, et al., “Hematopoietic differentiation in vitro of rhesus monkey embryonic stem cells,” Blood 92:368a (1998).
Salvagiotto G, et al., “Molecular profiling reveals similarities and differences between primitive subsets of hematopoietic cells generated in vitro from human embryonic stem cells and in vivo during embryogenesis”, Exp Hematol., 36(10):1377-1389 (2008).
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