Multipole ion guide for mass spectrometry

Radiant energy – Ionic separation or analysis – With sample supply means

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

250282, G01D 5944, H01J 4900

Patent

active

056524277

ABSTRACT:
A multipole ion guide which begins in one pumping stage and extends continuously into one or more subsequent pumping stages has been incorporated into an atmospheric pressure ion source mass spectrometer system. Ions delivered into vacuum from an Electrospray, Atmospheric Pressure Chemical Ionization or Inductively Coupled Plasma ion source are guided and focused into a mass analyzer with high efficiency using the multipole ion guide. The background pressure over a portion of the multipole ion guide length is high enough to cause kinetic energy cooling of ions traversing the ion guide length due to ion collisions with neutral background gas molecules. This ion kinetic energy cooling lowers energy spread of ions traversing the multipole ion guide length. The multipole ion guide DC offset potential can be used to adjust the mean ion energy and the ion guide a.sub.n and q.sub.n values can be set to reduce or expand the range of ion mass to charge which will be transmitted through the ion guide. These features of multipole ion guides and multiple pumping stage multipole ion guides are used to improve performance and lower the cost of Atmospheric Pressure Ion source mass spectrometer instruments.

REFERENCES:
patent: 4234791 (1980-11-01), Enke et al.
patent: 4328420 (1982-05-01), French
patent: 4480187 (1984-10-01), Matsuda
patent: 4486664 (1984-12-01), Wollnick
patent: 4535235 (1985-08-01), McIver, Jr.
patent: 4746794 (1988-05-01), French et al.
patent: 4842701 (1989-06-01), Smith et al.
patent: 4885076 (1989-12-01), Smith et al.
patent: 4963736 (1990-10-01), Douglas et al.
patent: 5157260 (1992-10-01), Mylchreest et al.
patent: 5160840 (1992-11-01), Vestal
patent: 5179278 (1993-01-01), Douglas
patent: 5349186 (1994-09-01), Ikonomou et al.
McIver R.T., Li Y., Hunter R.L., Matrix Assisted Laser Desorption/Ionization with an External Ion Source Fourier-Transform Mass Spectrometer, Rapid Communications in Mass Spectrometry, vol. 8, No. 3, p. 237-241 (1994).
Smith R.D., Olivares J.A., et al, Capillary Zone Electrophoresis . . . , Analyt, Chem., vol 60, pp. 436-441 (1988).
Olivares, J.A., Nguyen N.T., et. al., On-Line Mass Spectrometric Detection . . . , Analyt. Chem., vol. 5 pp. 1230-1232 (1987).
Beu, S.C., Senko M.W., et al., Fourier Transform Electrospray . . . , J. Am. Soc. Mass Spectrom., vol. 4, pp. 557-565 (1993).
Xu, H.J., Wada M., et al., A new cooling and focusing device for ion guide, Nuclear Instruments and Methods in Physics Research, vol. 333, pp. 274-282 (1993).
Boyle J., Whitehouse, C.M. and Fenn, J.B., An Ion Storage Time-of-Flight Mass Spectrometer . . . , Rapid Commun. in Mass Spectrom., vol. 5, pp. 400-405 (1991).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Multipole ion guide for mass spectrometry does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Multipole ion guide for mass spectrometry, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Multipole ion guide for mass spectrometry will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-635347

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.