Chemistry: analytical and immunological testing – Nuclear magnetic resonance – electron spin resonance or other...
Reexamination Certificate
2006-08-15
2006-08-15
Le, Long V. (Department: 1641)
Chemistry: analytical and immunological testing
Nuclear magnetic resonance, electron spin resonance or other...
C436S518000, C436S523000, C436S802000, C435S006120, C435S007100, C435S973000
Reexamination Certificate
active
07091046
ABSTRACT:
A system for analyzing expression levels and activity of a plurality of proteins is provided. A bio-displayed polypeptide binding component associated with a predetermined marker is used to bind the proteins of interest. The predetermined marker components are then amplified and detected in a high throughput manner.
REFERENCES:
patent: 4683202 (1987-07-01), Mullis
patent: 4797363 (1989-01-01), Teodorescu et al.
patent: 5223408 (1993-06-01), Goeddel et al.
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5288622 (1994-02-01), Gray et al.
patent: 5316922 (1994-05-01), Brown et al.
patent: 5348867 (1994-09-01), Georgiou et al.
patent: 5395750 (1995-03-01), Dillon et al.
patent: 5403484 (1995-04-01), Ladner et al.
patent: 5665539 (1997-09-01), Sano et al.
patent: 5741668 (1998-04-01), Ward et al.
patent: 5837500 (1998-11-01), Ladner et al.
patent: 5864137 (1999-01-01), Becker et al.
patent: 5866344 (1999-02-01), Georgiou
patent: 5939272 (1999-08-01), Buechler et al.
patent: 5965363 (1999-10-01), Monforte et al.
patent: 6051378 (2000-04-01), Monforte et al.
patent: 6090558 (2000-07-01), Butler et al.
patent: 6104028 (2000-08-01), Hunter et al.
patent: 6232107 (2001-05-01), Bryan et al.
patent: 6472146 (2002-10-01), Larocca et al.
patent: 6686154 (2004-02-01), Nock et al.
patent: 2002/0076727 (2002-06-01), Cardone et al.
patent: 2002/0142354 (2002-10-01), Wildsmith et al.
patent: 2002/0187464 (2002-12-01), Klempner et al.
patent: 2004/0142493 (2004-07-01), Hutchens et al.
patent: WO 97/44491 (1997-11-01), None
patent: 9910485 (1999-03-01), None
patent: 9956129 (1999-11-01), None
patent: 0029555 (2000-05-01), None
patent: 0123619 (2001-04-01), None
patent: 0184154 (2001-11-01), None
patent: 0194950 (2001-12-01), None
patent: 0239120 (2002-05-01), None
US 5,382,513, 01/1995, Lam et al. (withdrawn)
Arnheim et al., “Polymerase Chain Reaction”,C&EN, pp. 36-47, 1990.
Arnott et al., “An Integrated Approach to Proteone Analysis: Identification of Proteins Associated with Cardiac Hyperthophy”,Anal. Biochem., 258:1-18, 1998.
Barringer et al., “Blunt-End and Single-Strand Ligations byEscherichia coliLigase: Influence on an in vitro Amplification”,Gene, 89:117-122, 1990.
Black et al., “Random Sequence Mutagenesis for the Generation of Active Enzymes”,Methods in Mol. Biol., 57:335-349, 1996.
Boublik et al., “Eukaryotic Virus Display: Engineering the Major Surface Glycoprotein of theAutographa californicaNuclear Polyhedrosis Virus (AcNPV) for the Presentation of Foreign Proteins on the Virus Surface” ,Biotechnology, 13:1079-1084, 1995.
Bruchez et al., “Semiconductor Nanocrystals as Fluorescent Biological Label”,Science, 281:2013-2016, 1998.
Burritt et al., “Filamentous Phage Display of Oligopeptide Libraries”,Anal. Biochem., 238:1-13, 1996.
Celis et al., “2D Protein Electrophoresis: Can It Be Perfected?”,Curr. Opin. Biotechnol., 10:16-21, 1999.
Chee et al., “Accessing Genetic Information with High-Density DNA Arrays”,Science, 274:610-614, 1996.
Chiswell et al., “Phage Antibodies: Will New ‘Coliclonal’ Antibodies Replace Monoclonal Antibodies?”,Trends Biotechnol., 10:80-84, 1992.
Clackson et al., “Making Antibody Fragments Using Phage Display Libraries”,Nature, 352:624-628, 1991.
Easterling et al., “Monitoring Protein Expression in Whole Bacterial Cells with MALDI Time-of-Flight Mass Spectrometry”,Anal. Chem., 70(13):2704-2709, 1998.
Fannon, M., “Gene Expression in Nomrala nd Disease States—Identification of Therapeutic Targets”,Trends Biotechnol., 14:294-298, 1996.
Filippini et al., “A Novel Flow Cytometric Method for the Quantification of p53 Gene Expression”,Cytometry, 31;180-186, 1998.
Fodor, S., “Massively Parallel Genomics”,Science, 277:393-395, 1997.
Fodor, S., “Genes, Chips, and the Human Genome”,FASEB Journal, 11:A879, 1997.
Fu et al., “Isolation for Phage Display Libraries of Single Chain Variable Fragment Antibodies that Recognize Conformational Epitopes in the Malaria Vaccine Candidate, Apical Membrane Antigen-1”,J. Biol. Chem., 272(41):25678-25684, 1997.
Garden et al., “Excess Salt Removal with Matrix Rinsing: Direct Peptide Profiling of Neurons from Marine Invertebrates Using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry”,J. Mass Spectrom., 31:1126-1130, 1996.
Glaser et al., “Antibody Engineering by Codon-Based Mutagenesis in a Filamentous Phage Vector System”,J. Immunol., 149(12):3903-3913, 1992.
Gonzalez et al., “Intracellular Detection Assays for High-Throughput Screening”,Curr. Opin. Biotechnol., 9:624-631, 1998.
Griffiths et al., “Isolation of High Affinity Human Antibodies Directly from Large Synthetic Repertoires”,EMBO J., 13(14):3245-3260, 1994.
Guatelli et al., “Isothermal, in vitro Amplification of Nucleic Acids by a Multienzyme Reaction Modeled After Retroviral Replication”,Proc. Natl. Acad. Sci. USA, 87:1874-1878, 1990.
Hawkins et al., “A Magnetic Attraction to High-Throughput Genomics”,Science, 276:1887-1889, 1997.
Hill et al., “Phage Presentation”,Mol. Biol., 20(4):685-692, 1996.
Hoffman et al., Expression of Fully Functional Tetrameric Human Hemoglobin inEscherichia coli, Proc. Natl. Acad. Sci. USA, 87:8521-8525, 1990.
Hoogenboom et al., “Mutli-Subunit Proteins on the Surface of Filamentous Phage: Methologies for Displaying Antibody (Fab) Heavy and Light Chains”,Nucl. Acids Res., 19(15):4133-4137, 1991.
Houston et al., “The Chemical-Biological Interface: Developments in Automated and Miniaturised Screening Technology”,Curr. Opin. Biotechnol., 8:734-740, 1997.
Houston et al., “Rapid Analysis of Hemoglobin from Whole Human Blood by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry”,Rapid Commun. Mass Spectrom., 1:1435-1439, 1997.
Huse et al., “Generation of a Large Combinatorial Library of the Immunoglobin Repertoire in Phage Lambda”,Science, 246:1275-1281, 1989.
IUPAC-IUB Commission on Biochemical Nomenclature Symbols for Amino-Acid Derivatives and Peptides Recommendations (1971),Biochem., 11:942-944, 1972.
IUPAC-IUB Combined Commission on Biochemical Nomenclature Abbreviated Nonemclature of Synthetic Polypeptides (Polymerized Amino Acids)1-3Tentative Rules,J. Biol. Chem., 243(10):2451-2453, 1968.
Jessen et al., “Production of Human Hemoglobin inEscherichia coliUsing Cleavable Fusion Protein Expression Vector”,Methods Enzymol., 231:347-364, 1994.
Jimenez et al., “Ultramicroanalysis of Peptide Profiles in Biological Samples Using MALDI Mass Spectrometry”,Exp Nephrol., 6:421-428, 1998.
Kirk-Othmer Encyclopedia of Chemical Technology, vol. 5, Fourth Edition, pp. 1071-1094.
Kohler et al., “Continuous Cultures of Fused Cells Secretin Antibody of Predefined Specificity”,Nature, 256:495-497, 1975.
Kozian et al., “Comparative Gene-Expression Analysis”,Trends Biotechnol., 17:73-78, 1999.
Kwoh et al., “Transcription-based Amplification System and Detection of Amplified Human Immunodeficiency Virus Type 1 with a Bead-Based Sandwich Hybridization Format”,Proc. Natl. Acad. Sci. USA, 86:1173-1177, 1989.
Landegren et al., “A Ligase-Mediated Gene Detection Technique”,Science, 241:1077-1080, 1988.
Li et al., “Detection Limits for Matrix-assisted Laser Desorption of Polypeptides with an External Ion Source Fourier-transform Mass Spectrometer”,Rapid Commun. Mass Spectrom., 8:743-749, 1994.
Lomelli et al., “Quantitative Assays Based on the Use of Replicable Hybridization Probes”,Clin. Chem., 35(9):1826-1831, 1989.
Lowman, H.B., “Bacteriophage Display and Discovery of Peptide Leads for Drug Development”,Annu. Rev. Biophys. Biomol. Struct., 26:401-424, 1997.
Methods and Materials: Amplification of
Counts Gary W.
Fish & Richardson P.C.
HK Pharmaceuticals, Inc.
Le Long V.
Seidman Stephanie
LandOfFree
Multiplexed protein expression and activity assay does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Multiplexed protein expression and activity assay, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Multiplexed protein expression and activity assay will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3618466