Multiplexed molecular analysis apparatus and method

Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals

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422 62, 422 63, 422 67, 422 681, 422 81, 422105, 422112, 435 6, 4352861, 4352866, 4352865, 436 43, 436 50, 436524, 436525, 436527, 436531, G01N 33543

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060837632

ABSTRACT:
A method and apparatus for analyzing molecular structures within a sample substance using an array having a plurality of test sites upon which the sample substance is applied. The invention is also directed to a method and apparatus for constructing molecular arrays having a plurality of test sites. The invention allows for definitive high throughput analysis of multiple analytes in complex mixtures of sample substances. A combinatorial analysis process is described that results in the creation of an array of integrated chemical devices. These devices operate in parallel, each unit providing specific sets of data that, when taken as a whole, give a complete answer for a defined experiment. This approach is uniquely capable of rapidly providing a high density of information from limited amounts of sample in a cost-effective manner.

REFERENCES:
patent: 4883760 (1989-11-01), Heelies
patent: 5556762 (1996-09-01), Pinilla et al.
Fodor et al, "Light directed spatially addressable parallel chemical systesis", ScienceFeb. 15, 1991, vol. 251 at 767-773.

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