Multiplex gene regulation

Details Multiplex gene regulation Multiplex gene regulation

1988-08-24

1993-06-22

Chambers, Jasemine C.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

800DIG1, 800DIG4, 4351723, 4353171, 435948, 935111, 424 89, C12N 1500

Patent

active

052217787

ABSTRACT:
A transgenic mouse offspring produced by the mating of a first transgenic mouse carrying a transresponder transgene whose expression is regulated by a viral gene product of HSV-1 and a second transgenic mouse carrying a transactivator transgene. A process for expressing a gene of interest which comprises the mating of a first transgenic mouse carrying a transresponder transgene whose expression is regulated by a viral gene product of HSV-1 and a second transgenic mouse carrying a transactivator transgene.

REFERENCES:
patent: 4736866 (1988-04-01), Leder et al.
patent: 4873191 (1989-10-01), Wagner et al.
Van Brunt, Biotech. 6: 1149, 1151, 1152, 1154 (1988).
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Julien et al., Mol. Brain Res. 1: 243-250 (1986).
Jaenisch, Science 240: 1468-1474 (1988).
Hinrichs, S., et al, "A Transgenic Mouse Model for Human Neurofibromatosis" Science, vol. 237, 1340-1343.
Nerenberg, M., "The tat Gene of Human T-Lymphotropic Virus Type 1 Induces Mesenchymal Tumors in Transgenic Mice", Research Articles, Sep. 1987, II pp. 1324-1329.
Gorman, C., "Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells", Molecular and Cellular Biology, Sep. 1982, pp. 1044-1051.
O'Hare, Peter, "Comparison of Upstream Sequence Req. for Pos. and Neg. Reg. of Herpes Simplex Virus Immed-Early Gene by 3-Vir. Encoded trans-Acting Factors", Journal of Virology, Jan. 1987, pp. 190-199.
O'Hare, et al, "3 trans-Acting Reg. Proteins of Herp. Sim. Virus Modulate Immed.-Early Gene Exp. in Pathway Inv. Pos. and Neg., Feedback Reg.", Journal of Virology, Dec. 1985, pp. 723-733.
Nucleic Acids Research, vol. 16, #4, 1988, pp. 1423-1430.

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