Multiplex cellular assays using detectable cell barcodes

Details Multiplex cellular assays using detectable cell barcodes Multiplex cellular assays using detectable cell barcodes

2011-08-23

2011-08-23

Chen, Stacy B (Department: 1648)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

C435S007200

Reexamination Certificate

active

08003312

ABSTRACT:
We describe herein a cell-based multiplexing technique called detectable cell barcoding (DCB). In DCB, each individual sample is labeled with a different DCB signature that distinguishes each sample by one or both of detected intensity or type of detection characteristic. The samples are then combined and analyzed for a detectable characteristic of interest (e.g., presence of an analyte). By employing multiple distinct DCB labels at varying concentrations, one can perform multiplex analyses on up to hundreds or thousands (or more) of cell samples in a single reaction tube. DCB reduces reagent consumption by factors of 100-fold or more, significantly reduces data acquisition times and allows for stringent control sample analysis.

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