Multiplex analysis using membrane-bound sensitizers

Details Multiplex analysis using membrane-bound sensitizers Multiplex analysis using membrane-bound sensitizers

2005-09-27

2005-09-27

Le, Long V. (Department: 1641)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S004000, C435S007100, C435S007200, C436S514000, C436S516000, C436S518000, C436S535000

Reexamination Certificate

active

06949347

ABSTRACT:
The present invention is directed to methods and compositions for determining the presence, absence, and/or amounts of one or more membrane-associated analytes in a sample. In accordance with the invention, binding compounds derivatized with releasable molecular tags specifically bind to selected membrane-associated analytes, after which the molecular tags are released upon activation of cleavage moieties, or sensitizers, anchored in the same membrane as the membrane-associated analytes. The released molecular tags are then identified by their distinct separation and detection characteristics.

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