Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reexamination Certificate
2002-01-29
2004-06-15
Wortman, Donna C. (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
C435S347000, C435S373000, C435S455000
Reexamination Certificate
active
06750009
ABSTRACT:
BACKGROUND
1. Field of the Invention
The present invention generally relates to methods and compositions for screening for antiviral compounds using cell cultures. More specifically, the invention relates to the use of multiple cell cultures harboring multiple subgenomic viral replication systems to evaluate compounds for antiviral activity.
2. Description of the Related Art
REFERENCES CITED
1. Agapov, E. V., I. Frolov, B. D. Lindenbach, B. M. Pragai, S. Schlesinger, and C. M. Rice 1998. Noncytopathic Sindbis virus RNA vectors for heterologous gene expression Proc Natl Acad Sci USA. 95:12989-94.
2. Arroyo, J. I., S. A. Apperson, C. B. Cropp, B. J. Marafino, Jr., T. P. Monath, R. B. Tesh, R. E. Shope, and M. A. Garcia-Blanco 1988. Effect of human gamma interferon on yellow fever virus infection Am J Trop Med Hyg. 38:647-50.
3. Ballart, I., D. Eschle, R. Cattaneo, A. Schmid, M. Metzler, J. Chan, S. Pifko-Hirst, S. A. Udem, and M. A. Billeter 1990. Infectious measles virus from cloned cDNA Embo J. 9:379-84.
4. Barclay, W., Q. Li, G. Hutchinson, D. Moon, A. Richardson, N. Percy, J. W. Almond, and D. J. Evans 1998. Encapsidation studies of poliovirus subgenomic replicons J Gen Virol. 79:1725-34.
5. Behrens, S. E., C. W. Grassmann, H. J. Thiel, G. Meyers, and N. Tautz 1998. Characterization of an autonomous subgenomic pestivirus RNA replicon J Virol. 72:2364-72.
6. Blight, K. J., A. A. Kolykhalov, and C. M. Rice 2000. Efficient initiation of HCV RNA replication in cell culture Science. 290:1972-4.
7. Bredenbeek, P. J., I. Frolov, C. M. Rice, and S. Schlesinger 1993. Sindbis virus expression vectors: packaging of RNA replicons by using defective helper RNAs J Virol. 67:6439-46.
8. Bronstein, I., C. S. Martin, J. J. Fortin, C. E. Olesen, and J. C. Voyta 1996. Chemiluminescence: sensitive detection technology for reporter gene assays Clin Chem. 42:1542-6.
9. Burgart, L. J., R. A. Robinson, M. J. Heller, W. W. Wilke, O. K. Iakoubova, and J. C. Cheville 1992. Multiplex polymerase chain reaction Mod Pathol. 5:320-3.
10. Camenisch, G., M. Gruber, G. Donoho, P. Van Sloun, R. H. Wenger, and M. Gassmann 1996. A polyoma-based episomal vector efficiently expresses exogenous genes in mouse embryonic stem cells Nucleic Acids Res. 24:3707-13.
11. Clarke, D. K., M. S. Sidhu, J. E. Johnson, and S. A. Udem 2000. Rescue of mumps virus from cDNA J Virol. 74:4831-8.
12. Collins, P. L., M. G. Hill, E. Camargo, H. Grosfeld, R. M. Chanock, and B. R. Murphy 1995. Production of infectious human respiratory syncytial virus from cloned cDNA confirms an essential role for the transcription elongation factor from the 5′ proximal open reading frame of the M2 mRNA in gene expression and provides a capability for vaccine development Proc Natl Acad Sci USA. 92:11563-7.
13. Collins, P. L., M. G. Hill, J. Cristina, and H. Grosfeld 1996. Transcription elongation factor of respiratory syncytial virus, a nonsegmented negative-strand RNA virus Proc. Natl. Acad. Sci. USA. 93:81-85.
14. Constantinescu, N. 1991. [Molecular mechanisms of the antiviral effect of interferon] Rev Roum Virol. 42:191-213.
15. Conzelmann, K. K., and M. Schnell 1994. Rescue of synthetic genomic RNA analogs of rabies virus by plasmid-encoded proteins J Virol. 68:713-9.
16. Corey, D. R. 1997. Peptide nucleic acids: expanding the scope of nucleic acid recognition Trends Biotechnol. 15:224-9.
17. Davis, N. L., F. B. Grieder, J. F. Smith, G. F. Greenwald, M. L. Valenski, D. C. Sellon, P. C. Charles, and R. E. Johnston 1994. A molecular genetic approach to the study of Venezuelan equine encephalitis virus pathogenesis Arch Virol Suppl. 9:99-109.
18. Davis, N. L., L. V. Willis, J. F. Smith, and R. E. Johnston 1989. In vitro synthesis of infectious Venezuelan equine encephalitis virus RNA from a cDNA clone: analysis of a viable deletion mutant Virology. 171:189-204.
19. dos Santos, C. N., P. R. Post, R. Carvalho, Ferreira, II, C. M. Rice, and R. Galler 1995. Complete nucleotide sequence of yellow fever virus vaccine strains 17DD and 17D-213 Virus Res. 35:35-41.
20. Dryga, S. A., O. A. Dryga, and S. Schlesinger 1997. Identification of mutations in a Sindbis virus variant able to establish persistent infection in BHK cells: the importance of a mutation in the nsP2 gene Virology. 228:74-83.
21. Elnifro, E. M., A. M. Ashshi, R. J. Cooper, and P. E. Klapper 2000. Multiplex PCR: optimization and application in diagnostic virology Clin Microbiol Rev. 13:559-70.
22. Elroy-Stein, O., T. R. Fuerst, and B. Moss 1989. Cap-independent translation of mRNA conferred by encephalomyocarditis virus 5′ sequence improves the performance of the vaccinia virus/bacteriophage T7 hybrid expression system Proc Natl Acad Sci USA. 86:6126-30.
23. Fan, J., K. J. Henrickson, and L. L. Savatski 1998. Rapid simultaneous diagnosis of infections with respiratory syncytial viruses A and B, influenza viruses A and B, and human parainfluenza virus types 1, 2, and 3 by multiplex quantitative reverse transcription-polymerase chain reaction-enzyme hybridization assay (Hexaplex) Clin Infect Dis. 26:1397-402.
24. Frolov, I., E. Agapov, T. A. Hoffman, Jr., B. M. Pragai, M. Lippa, S. Schlesinger, and C. M. Rice 1999. Selection of RNA replicons capable of persistent noncytopathic replication in mammalian cells J Virol. 73:3854-65.
25. Frolov, I., T. A. Hoffman, B. M. Pragai, S. A. Dryga, H. V. Huang, S. Schlesinger, and C. M. Rice 1996. Alphavirus-based expression vectors: strategies and applications Proc Natl Acad Sci USA. 93:11371-7.
26. Geierstanger, B. H., M. Mrksich, P. B. Dervan, and D. E. Wemmer 1996. Extending the recognition site of designed minor groove binding molecules Nat Struct Biol. 3:321-4.
27. Geigenmuller, U., N. H. Ginzton, and S. M. Matsui 1997. Construction of a genome-length cDNA clone for human astrovirus serotype 1 and synthesis of infectious RNA transcripts J Virol. 71:1713-7.
28. Gow, J. W., M. M. McGill, W. M. Behan, and P. O. Behan 1996. Long RT-PCR amplification of full-length enterovirus genome Biotechniques. 20:582-4.
29. Grentzmann, G., J. A. Ingram, P. J. Kelly, R. F. Gesteland, and J. F. Atkins 1998. A dual-luciferase reporter system for studying recoding signals Rna. 4:479-86.
30. Grondahl, B., W. Puppe, A. Hoppe, I. Kuhne, J. A. Weigl, and H. J. Schmitt 1999. Rapid identification of nine microorganisms causing acute respiratory tract infections by single-tube multiplex reverse transcription-PCR: feasibility study J Clin Microbiol. 37:1-7.
31. Grosfeld, H., M. G. Hill, and P. L. Collins 1995. RNA replication by respiratory syncytial virus (RSV) is directed by the N, P, and L proteins; Ttranscription also occurs under these conditions but requires RSV superinfection for efficient synthesis of full-length mRNA J. Virol. 69:5677-5686.
32. Johnson, K. L., and L. A. Ball 1997. Replication of flock house virus RNAs from primary transcripts made in cells by RNA polymerase II J Virol. 71:3323-7.
33. Jungkind, D., S. Direnzo, K. G. Beavis, and N. S. Silverman 1996. Evaluation of automated COBAS AMPLICOR PCR system for detection of several infectious agents and its impact on laboratory management J Clin Microbiol. 34:2778-83.
34. Kapoor, M., L. Zhang, P. M. Mohan, and R. Padmanabhan 1995. Synthesis and characterization of an infectious dengue virus type-2 RNA genome (New Guinea C strain) Gene. 162:175-80.
35. Khromykh, A. A., and E. G. Westaway 1997. Subgenomic replicons of the flavivirus Kunjin: construction and applications J Virol. 71:1497-505.
36. Kinney, R. M., S. Butrapet, G. J. Chang, K. R. Tsuchiya, J. T. Roehrig, N. Bhamarapravati, and D. J. Gubler 1997. Construction of infectious cDNA clones for dengue 2 virus: strain 16681 and its attenuated vaccine derivative, strain PDK-53 Virology. 230:300-8.
37. Kwong, A. D., and N. Frenkel 1984. Herpes simplex virus amplicon: effect of size on replication of constructed defective genomes containing eucaryotic DNA sequences J Virol. 51:595-603.
38. Lai, C. J., B. T. Zhao, H. Hori, and M. Bray 1991. Infectious RNA transcribed from stably cloned full-length cDNA of dengue type 4 virus Proc Natl Acad Sci USA.
Dyall Julie
Olivo Paul D.
Romano Charles P.
Roth Robert M.
Amster Rothstein & Ebenstein LLP
Apath, LLC
Gendloff Elie H.
Wortman Donna C.
LandOfFree
Multiple viral replicon culture systems does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Multiple viral replicon culture systems, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Multiple viral replicon culture systems will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3308264