Multiple reactor system and method for polynucleotide synthesis

Details Multiple reactor system and method for polynucleotide synthesis Multiple reactor system and method for polynucleotide synthesis

1984-07-13

1985-05-14

Kight, John

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

525 541, 525 5423, 435287, 4351723, 435317, 435820, 935 88, 422116, 422131, C12M 100

Patent

active

045173389

ABSTRACT:
A reactor system and method for synthesizing or degrading polynucleotides and other linear polymers includes a tubular reactor connected to a reagent manifold. The polynucleotide is immobilized on a loosely packed solid-phase support material in the tubular reactor, and reagents are sequentially introduced into the tubular reactor. After each reagent is introduced, the tubular reactor is isolated from the reagent manifold and the reagent agitated by alternately pressurizing the opposite ends of the tubular reactor. The method provides rapid and efficient synthesis of polynucleotides. By connecting two or more tubular reactors to the reagent manifold, a plurality of polynucleotides having different sequences may be synthesized simultaneously.

REFERENCES:
patent: 4353989 (1982-10-01), Bender et al.
patent: 4373071 (1983-02-01), Itakura
patent: 4458066 (1984-07-01), Caruthers et al.
Alvarado-Urbino et al., Science, (1981), 214:270-274.
Matteucci et al., American Chemical Society, (1981), 103:3185-3191.
Smith, Am. Biotech. Lab., (1983), 1:15-24.

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