Multiple particulate antigen delivery system

Details Multiple particulate antigen delivery system Multiple particulate antigen delivery system

1995-06-30

1997-09-16

Mosher, Mary E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fusion protein or fusion polypeptide

4241881, 4241891, 4241901, 4242151, 4241871, 935 47, 935 65, 536 234, 435 693, 4352351, A61K 3915, A61K 39295, C12P 2102, C12P 1562

Patent

active

056677820

ABSTRACT:
Antigens in particulate form are provided wherein chimeric antigens having foreign epitopes are presented on or within virus-like particles (VLPs) or virus core-like particles (CLPs). The VLPs and CLPs are immunogenic and are useful in producing vaccine formulations.

REFERENCES:
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Kitson, J.D.A. et al. 1991. J. Virology, vol. 65, No. 6, pp. 3068-3075.
Lemon, S.M. et al. 1992. Virology vol. 188 pp. 285-295.
Norley, S. et al. Immunobiol. 184: 193-207 (1992).
Bowie, J et al. Science 247: 1306-1310 (1990).
Kumar, V. et al. Proc. Natl. Acad Sci 87: 1337-1341 (1990).
Roy, P. Trends. Microbiol. Jan. 8: 299-305, (1993).
French, T.J. et al. J. Virol. 64(12):5695-5700 (1990).
Eaton, B et al. Virology 180: 687-696 (1991).

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