Multiple monolayers of polymeric linkages on a solid phase for i

Details Multiple monolayers of polymeric linkages on a solid phase for i Multiple monolayers of polymeric linkages on a solid phase for i

1988-12-21

1990-06-12

Naff, David M.

Chemistry: molecular biology and microbiology

Carrier-bound or immobilized enzyme or microbial cell;...

Enzyme or microbial cell is immobilized on or in an organic...

435176, 435177, 435178, 436528, 530816, C12N 1106, C12N 1102, G01N 33544, C07K 1706

Patent

active

049332856

ABSTRACT:
The present invention provides a process for building an immobilized structure comprising multiple monolayers of effective sequential polymeric linkages. The multiple monolayers are built, monolayer by monolayer, from the surface of a solid phase, by an alternating reaction sequence conducted with multifunctional reagents. The process provides the capability of building numerous immobilized multiple monolayer structures wherein the length of each structure extending from a solid phase is substantially the same. Structures comprising multiple monolayers of polymeric linkages are useful for many purposes, as for example, immobilizing macromolecules or other biomolecules and the like to produce chemical or biochemical sensors. Other uses extend to molecular electronic applications, such as the production of molecular conductive wires and molecular circuitry. In a preferred embodiment, carbonyldiimidazole and phenylenediamine are the multifunctional reagents and multiple monolayers of phenylurethane linkages are produced.

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R. B. Merrifield, "Solid-Phase Peptide Synthesis", Biochemistry, vol. 3, No. 9, Sep., 1964.
J. Am. Chem. Soc. 1983, 105, pp. 674-676, A New Approach to Construction of Artificial Monolayer Assemblies, L. Netzer and J. Sagiv.

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