Multiple injector flow through dissolution cell for dissolution

Details Multiple injector flow through dissolution cell for dissolution Multiple injector flow through dissolution cell for dissolution

1980-06-25

1981-07-21

Cuchlinski, Jr., William A.

Chemical apparatus and process disinfecting, deodorizing, preser

Analyzer, structured indicator, or manipulative laboratory...

Sample mechanical transport means in or for automated...

422100, G01N 2113

Patent

active

042798604

ABSTRACT:
A dissolution cell for use in automatic dissolution testing apparatus is specially configured to accommodate the iterative insertion of product specimens into the dissolution mechanism flow stream, and to perform the specimen insertion into a stabilized flow stream with minimal insertion disturbance. A basic multiple-injection embodiment utilizes a linear configuration to selectively insert two specimens into the flow stream, and a circular multiple-injection embodiment teaches the selective insertion of a plurality of specimens into the stream in a manner amenable to a programmable sequence. Both embodiments use air evacuation of the specimen flow chamber prior to its insertion into the instrumented flow stream, and both allow a high degree of fidelity in the dissolution measurements performed. The improved cell is especially useful for testing rapidly dissolving industrial products or drug dosage forms.

REFERENCES:
patent: 3508879 (1970-04-01), Findl et al.
patent: 3684452 (1972-08-01), Bessman
patent: 3787291 (1974-01-01), Deuringer et al.
patent: 4019861 (1977-04-01), Dahms

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