Multiple emulsions comprising a hydrophobic continuous phase

Details Multiple emulsions comprising a hydrophobic continuous phase Multiple emulsions comprising a hydrophobic continuous phase

1997-08-07

1999-11-09

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424455, 514937, 514938, 514948, A61K 9127, A61K 966

Patent

active

059809361

ABSTRACT:
Multiple emulsions comprising a discontinuous emulsified phase incorporating a highly polar liquid, a second component selected from the group consisting of fluorocarbons and hydrocarbons and a continuous hydrophobic phase are disclosed. In preferred embodiments, the hydrophobic phase may comprise a fluorocarbon or hydrocarbon. Additionally, the stable multiple emulsions of the present invention may further incorporate a bioactive agent and are particularly suitable for drug delivery including pulmonary drug delivery.

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Grenier, et al. "Fluorinated Surfactants Intended for Biomedical Uses" Organofluorine Compounds in Medicinal Chemistry and Biomedical Applications, R. Filler, eds. pp. 339-379 (1993 Elsevier Science Publishers B.V.).
Safwat, et al. "The Formulation-Performance Relationship of Multiple Emulsions and Ocular Activity" J. of Controlled Release 32: 259-268 (1994) .

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