Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Reexamination Certificate
2005-06-07
2005-06-07
Devi, S. (Department: 1645)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
C530S350000, C530S323000, C530S825000, C530S331000, C530S806000, C514S002600, C424S244100, C424S234100, C424S190100, C424S184100
Reexamination Certificate
active
06903184
ABSTRACT:
The invention provides a nucleic acid encoding the 37-kDa pneumococcal surface adhesion A protein (PsaA) fromStreptococcus pneumoniae. The invention also provides purified polypeptides encoded by the nucleic acid encoding the 37-kDa protein from and the nucleic acids comprising unique fragment of at least 10 nucleotides of the 37-kDa protein. Additionally, multiple antigenic peptides that provide protection againstS. pneumoniaechallenge are provided. These multiple antigen peptides comprise the peptides that immunospecifically bind to the monoclonal antibodies. Also provided are vaccines comprising such immunogenic peptides, and methods of conferring protective immunity againstStreptococcus pneumoniaeinfection by administering therapeutic composition comprising the immunogenic peptides of the invention. Also provided are methods of detecting the presence ofStreptococcus pneumoniaein a sample using antibodies or antigens and methods of preventing and treatingStreptococcus pneumoniaeinfection in a subject.
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Ades Edwin W.
Carlone George M.
Johnson Scott E.
Jue Danny L.
Sampson Jacquelyn S.
Devi S.
Needle & Rosenberg P.C.
The United States of America as represented by the Secretary of
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