Multiphoton-excitation observation apparatus

Details Multiphoton-excitation observation apparatus Multiphoton-excitation observation apparatus

2007-03-22

2009-02-10

Porta, David P (Department: 2884)

Radiant energy

Luminophor irradiation

C250S459100, C359S385000

Reexamination Certificate

active

07488955

ABSTRACT:
The invention provides a multiphoton-excitation observation apparatus comprising a light-source unit for emitting pulsed laser light; an observation apparatus main unit for irradiating a specimen with laser light emitted from the light-source unit and observing fluorescence emitted from the specimen; an incidence adjusting device, disposed between the light-source unit and the observation apparatus main unit, for adjusting the beam diameter of the laser light emitted from the light-source unit; and a control apparatus for controlling the incidence-adjusting unit according to the depth of an observation plane in the specimen.

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Zipfel, W., “Nonlinear magic: multiphoton microscopy in the biosciences” Nature Biotechnology, vol. 21, No. 11, Nov. 2003, pp. 1369-1377, XP002444341 (p. 1375).
Wokosin, D., “All-Solid State Ultrafast Lasers Facilitate Multiphoton Excitation Fluorescence Imaging”, IEEE Journal of Selected Topics in Quantum Electronics, vol. 2, No. 4, 1996, pp. 1051-1065, XP002444342, pp. 1058-1061.
So, Peter T., “Two-Photon Excitation Fluorescence Microscopy”, Annu. Rev. Biomed. Eng., vol. 2, 2000, pp. 399-429, XP002444343, pp. 416 and 417.

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