Multiparticulate pharmaceutical form with programmed and pulsed

Details Multiparticulate pharmaceutical form with programmed and pulsed Multiparticulate pharmaceutical form with programmed and pulsed

1999-01-13

2000-03-21

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424494, 424456, A61K 914

Patent

active

060399791

ABSTRACT:
The invention relates to a multiparticulate pharmaceutical form with delayed and pulsed release, enabling to obtain the onset of the availability of the active ingredient within 4 to 8 hours after the ingestion of the pharmaceutical form, and then a progressive release of the totality of the active ingredient within the 8 to 20 following hours, characterized by the fact that it is free of organic acid and that it is in the form of medicinal spheroids consisting of a neutral spherical core comprising a first coating based on a mixture of at least one hydrosoluble polymer and of at least one non hydrosoluble polymer throughout which are uniformly distributed the constitutive particles of an active ingredient, the whole comprising a second coating based on at least two pH independent polymers presenting rates of permeability different from one another with respect to the gastric and intestinal mediums, optionally at least one pH dependent polymer, at least one plasticizer and at least one inert carrier uniformly distributed throughout the said coating.

REFERENCES:
patent: 5508044 (1996-04-01), Buxton et al.
patent: 5567441 (1996-10-01), Chen
patent: 5705092 (1998-01-01), Wellinghoff et al.
"An organic Acid-Induced Sigmoidal Release System for Oral Controlled-Release Preparations", Pharmaceutical Research, vol. 11, No. 1 (1994), pp. 111-116.

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