Multimers of the soluble forms of TNF receptors, their preparati

Details Multimers of the soluble forms of TNF receptors, their preparati Multimers of the soluble forms of TNF receptors, their preparati

1992-08-07

1995-12-26

Walsh, Stephen G.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Lymphokines, e.g., interferons, interlukins, etc.

424 851, 424450, 4241581, C07K 14525, A61K 4500

Patent

active

054789257

ABSTRACT:
Multimers of the soluble forms of the tumor necrosis factor receptors (TNF-Rs) are provided. These multimers are produced either by chemical or by recombinant methods. The multimers of the soluble forms of TNF-Rs are useful for protecting mammals (including humans) from the deleterious effects of TNF.

REFERENCES:
patent: 4837028 (1989-06-01), Allen
Loetscher et al. 1991 J. Biol Chem. 266:18324-18329.
Peppel et al. 1991 J. Exp. Med. 174:1483-1489.
Peppel et al. 1993 J. Immunology 151:5699-5703.
Lesslauer et al. 1991 Eur. J. Immunol 21:2883-2886.
Mohler et al 1993 J. Immunol 151:1548-1561.
Seckinger et al. 1989 J. Biol. Chem. 264:11966-11973.
Engelmann et al 1990 J. Biol. Chem. 265:1531-1536.
Himmler et al. 1990 DMNA Cell Biol. 9: 705-715.
Utsumi et al 1991 Cancer Res 51:3362-3366.
Debs et al 1989 J. Immunol. 143:1192-1197.
Smith et al. 1989 J. Biol. Chem. 264:14646-14652.
B. Beutler, A. Cerami, "Tumor, Necrosis, Cachexia, Shock, and Inflammation: A Common Mediator," Annual Review Biochemistry, 1988, 57:505-518.
L. J. Old, "Tumor Necrosis Factor", Scientific American, 1988, 258:41-49.
J. Frere, C. Gerday, "Les Methodes de Purification et d'Analyse des Proteines", Masson, Paris, France 1981, pp. 48-49.

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