Multimeric, recombinant urease vaccine

Details Multimeric, recombinant urease vaccine Multimeric, recombinant urease vaccine

1997-08-26

1998-11-17

Jacobson, Dian C.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

4242341, 435227, 514925, 514926, 514927, A61K 3846, A61K 3902, A61K 39106

Patent

active

058372407

ABSTRACT:
Methods and compositions are provided for prophylactic and antibacterial therapy for Helicobacter, particularly for Helicobacter pylori, infection of humans. The immunogenic composition of the invention is composed of a plurality of multimeric complexes, each complex being composed of recombinant, enzymatically inactive Helicobacter pylori urease. Each multimeric complex is composed of six Urease A subunits and six Urease B subunits. Alternatively, the composition is composed of a mixture of multimeric complexes, wherein each multimeric complex in the mixture is composed of six Urease A subunits and six Urease B subunits or four Urease A subunits and four Urease B subunits.

REFERENCES:
Michetti, P. et al., Gastroenterology 107(4):1002-1011 (1994).
Davin, C. et al., Gastroenterology 104(4):A1035 (1993).
Pallen, M.J. et al., Lancet 336:156-157 (1990).
Hu, Li-Tai et al., Infection and Immunity, vol. 60, No. 7, (Jul. 1992), pp. 2657-2666.

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