Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-12-22
1999-11-02
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 11, 530317, A61K 3800
Patent
active
059770643
ABSTRACT:
This invention relates to antithrombotic agents and uses thereof. Specifically, the invention relates to chemical moieties that specifically bind to platelets and inhibit their aggregation, including linear and cyclic peptides. The invention provides methods for using these antithrombotic agents to prevent the formation of thrombi at sites in a mammalian body. In particular, the platelet-specific binding moieties including linear and cyclic peptides of the invention are covalently linked to a polyvalent linker moiety, so that the polyvalent linker moiety is covalently linked to a multiplicity of the platelet-specific binding moieties including linear and cyclic peptides. Effficacious antithrombotic agents are thereby provided.
REFERENCES:
patent: 4578079 (1986-03-01), Ruoslahti et al.
patent: 4614517 (1986-09-01), Ruoslathi et al.
patent: 4792525 (1988-12-01), Ruoslahti et al.
patent: 5185433 (1993-02-01), Dean et al.
patent: 5338725 (1994-08-01), Ojima et al.
patent: 5508020 (1996-04-01), Dean et al.
Piersch bacher et al. J. Biol. Chem. 262(36) Dec. 25, 1987 pp. 17294-17298.
Ojima et al., 1992, 204th Meeting, Amer. Chem. Soc. Abst. 44.
Cheronis, "Bissuccinimidealkane Peptide Dimres" (1992) J. Med. Chem., v. 35, No. 9, pp. 1563-1572 (May 1, 1992).
Pierschbacher et al. "influence storeochemistry RGD" (1987) J. Biol. Chem., v. 262, No. 36, pp. 17294-17298.
Andrieux et al., "Platelet Fibronogen receptors" (1987) Caplus #1988:490296.
S. Basjus 2, "Significance D. Amino Acids is Peptides" (1979) Pharmazi, m. 5/6.
Hrub, et al., "Conformational Restrictions of Biologically Have Peptide" Life Science (Jul. 19, 1982), v. 31(3), pp. 189-199.
Dean Richard T.
Lister-James John
Delaney Patrick R.
Diatide, Inc.
McDaniels Patricia A.
Noonan Kevin E.
Tsang Cecilia J.
LandOfFree
Multimeric polyvalent antithrombotic agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Multimeric polyvalent antithrombotic agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Multimeric polyvalent antithrombotic agents will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2135502