Multimeric molecules, the preparation method thereof and use...

Details Multimeric molecules, the preparation method thereof and use... Multimeric molecules, the preparation method thereof and use...

2003-05-28

2010-06-22

Kosar, Andrew D (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S317000

Reexamination Certificate

active

07741280

ABSTRACT:
The invention relates to a multimeric molecule which can imitate a natural multimeric proteinaceous ligand. The invention also relates to a multimeric molecule as defined above which is characterised in that it has the following general formula: A-Xn, wherein: n is equal to 3, 4, 5 or 6; A denotes a chemical group which is functionalised by at least three amine functions or COOH functions; and X denotes a D, B-D or B(D)-D′ group, in which B is a spacer and D and D′ are peptides or pseudopeptides corresponding to a sequence which is derived from the ligand and selected from residual matter forming the interface with the receptor and which can interact with the receptor.

REFERENCES:
patent: WO 99/52877 (1999-10-01), None
patent: WO 01/42298 (2001-06-01), None
patent: WO 01/49866 (2001-07-01), None
patent: WO 02/00893 (2002-01-01), None
Vaccine Development and Testing, accessed at http://www.hhs.gov
vpo/factsheets/fs—tableII—doc1.htm, 4 pages, last updated Aug. 2001.
M. Habib et al. J. Immunol. (2007) 178(11), pp. 6700-6704.
G Aversa et al.: “CD40 ligand-CD40 interaction in Ig isotype switching in mature and immature human B cells” Seminars in Immunology., vol. 6, 1994, pp. 295-301, XP002237774 W.B. Saunders Company, PA., US ISSN: 1044-5323 the whole document.
L E Haswell et al.: “Analysis of the oligomeric requirements for signaling by CD40 using soluble multimeric forms of its ligans, CD154” European Journal of Immunology vol. 31, No. 10, Oct. 2001, pp. 3094-3100, XP002237771 Weinheim, DE ISSN: 0014-2980.
Y-M Hsu et al.: “Heteromultimeric complexes of CD40 ligand are present on the cell surface of human T lymphocytes” Journal of Biological Chemistry., vol. 272, No. 2, 1997, pp. 911-915, XP002237772 American Society of Biological Chemists, Baltimore, MD., US ISSN: 0021-9258.
Archives of Biochemistry and Biophysics, vol. 392, No. 2, Aug. 15, 2001, pp. 208-218, XP002237773 New York, US, US ISSN: 0003-9861.

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