Multimeric hybrid gene encoding a chimeric protein which confers

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4352523, 43525232, 4352531, 536 2372, 935 27, 935 32, 935 72, C12N 2106, C12N 120, C12N 1500, C07N 2104

Patent

active

059981695

ABSTRACT:
Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory syncytial virus (RSV). A single recombinant immunogen is capable of protecting infants and similar susceptible individuals against diseases caused by both PIV and RSV.

REFERENCES:
patent: 4578269 (1986-03-01), Morein
patent: 4722898 (1988-02-01), Paoletti et al.
patent: 4866034 (1989-09-01), Ribi
patent: 4879213 (1989-11-01), Fox et al.
patent: 4950480 (1990-08-01), Barber et al.
patent: 5098998 (1992-03-01), Mekalonos et al.
patent: 5110587 (1992-05-01), Paoletti et al.
Murphy et al; Experimental Lung Research, 2:97-109 (1981).
Porter et al; J. of Virology, Jan. 1991, p. 103-111, vol.65, No. 1.
Kapikan et al Am. J. Epidemiology 89, 1969, p. 405-421.
Roy et al, J. Inf. Diseases. 157(4): 648-659 (1988).
Stover et al, Nature, 351:456-460 (1991).
Olmstead et al, PNAS, 83: 7462-7466 (1986).
Hall et al, Science 265:1393-1394 (1994).
Bushe et al J. Inf. Dis. 145, 1982, P. 311-319.
Ray et al, (1989) Virus Research, 12:169-180.
Coelingh et al, (1987) Virology, 160: 465-472.
Wathen et al, (1989) J. of Inf. Dis. 159:255-263.
Spriggs et al, (1987) J. Virol. 61:3416-3423.
Stott et al, (1987) J. Virol. 61:3855-3861.
Wathen et al, (1989) J. Gen Virol. 70:2625-2635.
Brideau et al, (1989) J. Gen. Virol. 70:2637-2644.
Goebel et al, (1990) Virology 179:247-266.
Perkus et al (1990) Virology 179:276-286.
Goebel et al (1990) Virology 179:517-563.
Conners et al, (1992) Vaccine 10:475-484.
Targaglia et al (1992) Virology 188:217-232.
Piccini et al, (1987) Methods in Enzymology, 153:545-563.
Taylor et al, (1990) J. Virology, 64:1441-1450.
Collins, P., (1990) J. Virol, 64: 4007-4012.
Vijaya S., et al, (1988) Mol. Cell Biol. vol. 8, No. 4; 1709-1714.
Perkus et al (1989) J. Virology 63:3829-3836.
Bowie et al, Science 247: 1306-1310 (1990).
Kumar et al, PNAS 87:1337-1347 (1990).
Lazar et al, Molecular and Cellular Biology 8(3):1247-1252 (1988).
Burges et al, Journal of Cell Biology 111:2129-2138 (1990).
Chanock et al; Pediatrics vol. 90, No. 1, Jul. 1992 pp. 137-143.
Kasel et al; J. of Virology, Dec. 1984, pp. 828-832, vol. 52, No. 3.
Prince et al; Am. J. of Pathology, vol. 93, #3, 771-783, 1978.
Prince et al; J. of Virology 57; 721-728; Mar. 1986.
Tizard, et al "An Introduction to Veterinary Immunology", 2.sup.nd ed, published by Saunders (Philadelphia-pp. 123-124).
Hendry et al (J. Gen. Virol. 64(8) pp. 3833-3843) Aug. 1990.
Coelingh et al (Journal of Virology vol. 63(9) pp. 3755-3760) Sep. 1989.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Multimeric hybrid gene encoding a chimeric protein which confers does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Multimeric hybrid gene encoding a chimeric protein which confers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Multimeric hybrid gene encoding a chimeric protein which confers will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-822598

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.