Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Reexamination Certificate
2006-05-02
2006-05-02
Kunz, Gary (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
C530S350000, C530S358000
Reexamination Certificate
active
07038022
ABSTRACT:
In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact to form multimeric species comprising a complex of more than one receptor. Accordingly, the interaction of a first receptor species with a second receptor species modulates the ability of the first receptor species to trans-activate transcription of genes maintained under hormone expression control in the presence of the cognate ligand for said first receptor.
REFERENCES:
patent: WO 93/13129 (1993-07-01), None
patent: WO 93/15216 (1993-08-01), None
Glass et al. 1989 Cell 59:697-708.
Mandelsdorf et al 1990. Nature 345:224.
Glass Endocrine Reviews 15:391-407, 1994.
Forman et al. The New Biologist 2(1990) 587-594.
Fawell et al. Cell 60(1990) 953-962.
De Luca, L. M., “Retinoid and their receptors in differentiation, embryogenesis, and neoplasia”The FASEB Journal, 5:2924-2933 (1991).
Kliewer et al., “Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling”PNAS USA, 89:1448-1452 (1992).
Tsai et al., Interactions between a DNA-Binding Transcription Factor (COUP) and a Non-DNA Binding Factor (S300-II)Cell, 50: 701-709 (1987).
Issemann & Green, “Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators”Nature347:645-650 (1990).
Ladias and Karathanasis, “Regulation of the Apolipoprotein AI Gene by ARP-1, a Novel Member of the Steroid Receptor Superfamily”Science251:561-565 (1991).
Mangelsdorf et al., “A Direct Repeat in the Cellular Retinol-Binding Protein Type II Gene Confers Differential Regulation by RXR and RAR”Cell55:555-561 (1991).
Mlodzik et al., “The Drosophila seven-up Gene, a Member of the Steroid Receptor Gene Superfamily, controls Photoeceptor Cell Fates”Cell60:211-224 (1990).
Miyajima et al., “Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other”Nucleic Acids Research16:11057-11074 (1988).
Oro et al., “Relationship between the product of theDrosophila ultraspiraclelocus and the vertebrate retinoid×receptor”Nature347:298-301 (1990).
Rivier et al., “Synthetic Competitive Antagonists of Corticotropin-Releasing Factor: Effect on ACTH Secretion in the Rat” 224:889-891 (1984).
Schüle et al., “Functinal Antagonism between Oncoprotein c-Jun and the Glucocorticoid Receptor”Cell62:1217-1226 (1990).
Sladek et al., “Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily”Genes&Devel.4:2353-2365 (1990).
Smith and Johnson, “Single-step purification of polypeptides expressed inEscherichia colias fusions with glutathione S-transferase” Gene 67:31-40 (1988).
Studier et al., “Use of T7 RNA Polymerase to Direct Expression of Cloned Genes”Meth. Enzymol.185:60-89 (1990).
Umesono et al., “Direct Repeats as Selective Response Elements for the Thyroid Hormone, Retinoic Acid, and Vitamin D3Receptors” Cell 65:1255-1265 (1991).
Vaughan et al., “Detection and Purification of Inhibin Using Antisera Generated against Synthetic Peptide Fragments”Meth. in Enzymol.168: 588-617 (1989).
Wang et al., “COUP transcription factor is a member of the steriod receptor superfamily”Nature340:163-166 (1989).
Evans Ronald M.
Kliewer Steven A.
Umesono Kazuhiko
Foley & Lardner
Hayes Robert
Kunz Gary
Reiter Stephen E.
The Salk Institute for Biological Studies
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