Multimeric forms of human rhinovirus receptor protein

Details Multimeric forms of human rhinovirus receptor protein Multimeric forms of human rhinovirus receptor protein

1995-06-05

1999-02-16

Cunningham, Thomas M.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Structurally-modified antibody, immunoglobulin, or fragment...

4241391, 4241431, 4241471, 4241521, 5303871, 53038822, 5303883, A61K 3944, C07K 1628

Patent

active

058717331

ABSTRACT:
The present invention relates to novel forms and configurations of intercellular adhesion molecule (ICAM) including multimeric configurations that effectively bind to human rhinovirus and can effectively reduce HRV infectivity. When in a multimeric configuration, preferably as dimers, these proteins display enhanced binding of HRV and are able to reduce HRV infectivity as well as the infectivity of other viruses known to bind to the "major" group human rhinovirus receptor (HRR). The multimerized proteins may also be used to block tICAM interaction with lymphocyte function-associated antigen-1 (LFA-1).

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