Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Wearing apparel – fabric – or cloth
Patent
1995-10-10
1997-08-19
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Wearing apparel, fabric, or cloth
424404, 424444, 428113, 602 45, A01N 2534, A61L 1516, B32B 522, B32B 1702
Patent
active
056585829
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a new material, i.e., a multilayer nonwoven tissue, wherein one of the layers comprises a hyaluronic acid derivative.
2. Description of Related Art
Studies aimed at obtaining biomaterials composed of hyaluronic acid esters used as such or in mixtures with other polymers, which provide good skin coverage, have led to the creation of various types of products. Tissues such as the gauzes and films described in U.S. Pat. Nos. 4,851,521 and 4,965,353 have been proposed. Limitations on the use of such products as skin coverings are due to their degree of rigidity, which may vary according to how they are made, and to their poor absorption of fluids, such as those exuding from wounds during tissue repair. By using nonwoven tissue production techniques, it is possible to obtain products which combine flexibility with the capacity to strongly absorb fluids. These characteristics are described in various patents, such as U.S. Pat. No. 5,041,104.
Limitations on the use of products composed of hyaluronic acid derivatives and/or their mixtures, obtained using currently known techniques, can for the most part be attributed to:
(1) the poor mechanical characteristics of the material when wet, due to its tendency to form a gel when it comes into contact with aqueous fluids such as physiological fluids;
(2) the excessive use of expensive materials such as hyaluronic acid derivatives or mixtures thereof with other biocompatible and bioabsorbable polymers, resulting in a high cost of the finished product, despite the fact that the polymer need only be present in the layer directly in contact with the application site; and
(3) excessively high vapour transmission values.
These drawbacks are particularly significant in cases where poor exudate production is present.
SUMMARY OF THE INVENTION
Accordingly, an object of the present invention is to provide a multilayer nonwoven material, comprising a surface layer which comes into contact with the skin, and one or more other layers which do not come into contact with the skin, wherein said surface layer which comes into contact with the skin is a member selected from the group consisting of a surface layer comprising at least one derivative of hyaluronic acid, a surface layer comprising a mixture of said at least one derivative of hyaluronic acid and at least one natural polymer, semisynthetic polymer, or synthetic polymer, and a surface layer comprising a natural, synthetic, or semisynthetic biocompatible perforated membrane compatible with cell growth on its surface. In a preferred embodiment, the layer which contacts the skin comprises a hyaluronic acid derivative, i.e., a compound containing a hyaluronic acid moiety, especially a hyaluronic acid ester or mixtures thereof.
Such products possess good mechanical and fluid absorption characteristics, are flexible and soft, reasonably priced, and can be varied with respect to their permeability to water vapours.
Another object of the present invention is to provide a multilayer nonwoven material, wherein said one or more other layers which do not come into contact with the skin comprise a natural, synthetic, or semisynthetic material which acts as a reinforcement and/or a fluid absorption system for said multilayer nonwoven material, thus reducing the quantity of biocompatible and bioabsorbable polymers to a minimum, concentrating their action in the area where it is needed.
A further object of the present invention is to provide a multilayer nonwoven material as above, wherein said surface layer which comes into contact with the skin and said one or more other layers which do not come into contact with the skin are fixed together by at least one member selected form the group consisting of a coagulating chemical agent, an adhesive agent, and mechanical stitches.
Such multilayer nonwoven materials can be used, for example, as non-adhesive sanitary or surgical articles in surgery, in dermatology such as in treating skin pathologies, in odontost
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Callegaro Lanfranco
Dorigatti Franco
Fidia Advanced Biopolymers S.r.l.
Page Thurman K.
Shelborne Kathryne E.
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