Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1987-11-17
1990-12-04
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
A61K 3722
Patent
active
049752820
ABSTRACT:
A multilamellar vesicle dispersed in an aqueous phase comprising an aqueous medium, a lipid concentration of at least about 50 mg/ml and a trapping efficiency of at least about 40 percent. The vesicle can be prepared by dispersing the lipid in an aqueous phase to form a multilamellar vesicle, rapidly freezing the multilamellar vesicle to obtain a frozen lipid-aqueous medium mixture, and warming the mixture to obtain a frozen and thawed multilamellar vesicle dispersed in an aqueous phase.
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Bally Marcel B.
Cullis Pieter R.
Hope Michael J.
Janoff Andrew S.
Mayer Lawrence D.
Bloom Allen
Henley III Raymond J.
Kurtz Catherine L.
Robinson Douglas W.
The Liposome Company Inc.
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