Multigene diagnostic assay for malignant thyroid neoplasm

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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Reexamination Certificate

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07901888

ABSTRACT:
The present invention provides methods for diagnosing, providing a prognosis, and staging thyroid cancer, using panels of molecular markers that are differentially expressed in thyroid cancer. Also provided are methods to identify compounds that are useful for the treatment or prevention of thyroid cancer.

REFERENCES:
Kebebew et al I (Cancer, Jun. 2006, 106:2592-2597).
Kebebew et al II (Surgery, Dec. 2005, 138:1102-1110, IDS).
Kebebew et al Ill (Annals of Surgery, Sep. 2005, 242:353-363).
Kebebew, M.D., Electron, et al. “Diagnostic and Extent of Disease Multigene Assay for Malignant Thyroid Neoplasm,” American Cancer Society, 2006, pp. 2592-2597.
Kebebew, M.D., Electron, et al. “Predictors of Single-Gland vs Multigland Parathyroid Disease in Primary Hyperparathyroidism; A simple and accurate Scoring Model,” American Medical Association, 2006, pp. 777-782.
Kebebew, M.D., Electron, et al. “Diagnostic and value of angiogenesis-modulating genes in malignant thyroid neoplasms,” Surgery, 2005, vol. 138, No. 6, pp. 1102-1110.
Kebebew, M.D., Electron, et al. “Diagnostic and Prognostic Value of Cell-cycle Regulatory Genes in Malignant Thyroid Neoplasms,” World J. Surg, 2006, vol. 30, pp. 767-774.

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