Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Processes of preparing a desired or intentional composition...
Patent
1991-06-17
1993-01-26
Page, Thurman K.
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Processes of preparing a desired or intentional composition...
523113, 530812, 530815, 530816, 604266, A01N 100
Patent
active
051823179
ABSTRACT:
The present invention is directed to multifunctional thrombo-resistant coatings for use with biomedical devices and implants, such as a coating which includes a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A plurality of different bioactive molecules, designed to counteract specific blood-material incompatibility reactions, are covalently bonded to poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chain. The method of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is achieved by plasma etching with ammonia gas or by plasma polymerization of a siloxane monomer in the presence of ammonia gas. The amine-containing siloxane surface is reacted with poly(ethylene oxide) chains terminated with functional groups capable of reacting with the amine groups on the siloxane surface. The material is then reacted with a plurality of different bioactive molecules which counteract the specific blood-material incompatibility reactions, such that a single bioactive molecule is coupled to a single poly(ethylene oxide) chain. The resulting siloxane surface contains a plurality of different bioactive molecules capable of reacting with blood components which come in proximity to the siloxane surface in order to resist blood-material incompatibility reactions.
REFERENCES:
patent: 310781 (1974-05-01), Eriksson et al.
patent: 3279996 (1966-10-01), Long, Jr. et al.
patent: 3453194 (1969-07-01), Bennett et al.
patent: 3522346 (1970-07-01), Chang
patent: 3629141 (1972-02-01), Dyck
patent: 3673612 (1972-07-01), Merrill et al.
patent: 3759788 (1973-09-01), Gajewski et al.
patent: 3826678 (1974-07-01), Hoffman
patent: 3846353 (1974-11-01), Grotta
patent: 3865615 (1975-02-01), Manly
patent: 3888833 (1975-06-01), Lednicer et al.
patent: 3940506 (1976-02-01), Heinecke
patent: 3959128 (1976-05-01), Harris
patent: 3969240 (1976-07-01), Kolobow et al.
patent: 3992495 (1976-11-01), Sano et al.
patent: 4008047 (1977-02-01), Petersen
patent: 4059512 (1977-11-01), Harris
patent: 4061141 (1977-12-01), Hyden et al.
patent: 4093515 (1978-06-01), Kolobow et al.
patent: 4170559 (1979-10-01), Kroplinski et al.
patent: 4210529 (1980-07-01), Petersen
patent: 4213962 (1980-07-01), Miura et al.
patent: 4214020 (1980-07-01), Ward et al.
patent: 4243776 (1981-01-01), Marconi et al.
patent: 4329383 (1982-05-01), Joh
patent: 4331697 (1982-05-01), Kudo et al.
patent: 4349467 (1982-09-01), Williams et al.
patent: 4378803 (1983-04-01), Takagi et al.
patent: 4410338 (1983-10-01), Yamamoto et al.
patent: 4444662 (1984-04-01), Conover
patent: 4483901 (1984-11-01), Okita et al.
patent: 4500676 (1985-02-01), Balazs
patent: 4521564 (1985-06-01), Solomon et al.
patent: 4600652 (1986-07-01), Solomon et al.
patent: 4613517 (1986-09-01), Williams et al.
patent: 4613665 (1986-09-01), Larm
patent: 4622206 (1986-11-01), Torgeson
patent: 4666668 (1987-05-01), Lidorenko et al.
patent: 4673584 (1987-06-01), Nygren et al.
patent: 4686975 (1987-08-01), Naimon et al.
patent: 4770852 (1988-09-01), Takahara et al.
patent: 4781889 (1988-11-01), Fukasawa et al.
patent: 4806246 (1989-02-01), Nomura
patent: 4806595 (1989-02-01), Noishiki et al.
patent: 4810784 (1989-03-01), Larm
patent: 4822741 (1989-04-01), Banes
patent: 4824444 (1989-04-01), Nomura
patent: 4828561 (1989-05-01), Woodroof
patent: 4844986 (1989-07-01), Karakelle et al.
patent: 4846844 (1989-07-01), De Leon et al.
patent: 4861830 (1989-08-01), Ward, Jr.
patent: 4872867 (1989-10-01), Joh
patent: 4879135 (1989-11-01), Greco et al.
patent: 4919659 (1990-04-01), Horbett et al.
patent: 5004461 (1991-04-01), Wilson
patent: 5013717 (1991-05-01), Solomon et al.
patent: 5019393 (1991-05-01), Ito et al.
patent: 5026607 (1991-06-01), Kiezulas
patent: 5053048 (1991-10-01), Pinchuk
patent: 5053453 (1991-10-01), Ku
patent: 5061738 (1991-10-01), Solomon et al.
Bell, A. T. et al., "A Study of the Performance and Chemical Characteristics of Composite Reverse Osmosis Membranes Prepared by Plasma Polymerization of Allylamine," Journal of Applied Polymer Science, vol. 19, pp. 1911-1930 (1975).
Buijten, J. et al., "Immobilization of Polyethylene Glycon in Capillary Columns for Gas Chromatography," J. Chromat., 268, pp. 387-394 (1983).
Chawla, Attar S., "Use of Plasma Polymerization for Preparing Silicone-Coated Membranes for Possible Use in Blood Oxygenators," Artificial Organs, vol. 3, No. 1, pp. 92- 96 (Feb. 1979).
Chung-Peng, Ho et al., "Modification of Silicone Contact Lenses by Plasma Plasma Polymerization and Subsequent Plasma Treatments," University of Missouri-Rolla, pp. 705-709 (undated).
Denaro, A. R. et al., "Glow Discharge Polymerization--III Allyl Alcohol and Crotyl Alcohol," Euro. Poly. J., vol. 6, pp. 487-497 (1970).
Doblhofer, K. et al., "Electrochemical Performance of Fixed-Charge Polymer Films Prepared on Electrodes by Plasma Polymerization," Thin Solid Films, vol. 118, pp. 181-185 (1984).
Elam, E. H. et al., "Covalent Coupling of Polysaccarides to Silicon and Silicon Rubber Surfaces," J. Biomed. Mater. Res., vol. 18, pp. 953-959 (1984).
Gombotz, Wayne et al., "Immobilized Enzymes in Blood Plasma Exchanges via Radiation Grafting," Radiat. Phys. Chem., vol. 25, Nos. 4-6, pp. 549-556 (1985).
Gombotz, W. R. et al., "Functionalization of Polymeric Films by Plasma Polymerization of Allyl Alcohol and Allylamine," ACS Symposium Abstracts, vol. 56 (1987).
Gregonis, D. E. et al., "Poly(Ethylene Glycol) Surfaces to Minimize Protein Absorption," Second World Congress on Biomaterials Abstracts, 10th Annual Meeting of the Society of Biomaterials, Wash., D.C. (1984).
Hoffman, Allan S., "Blood-Biomaterial Interactions: An Overview," American Chemical Society, pp. 3-8 (1982).
Hollahan, J. R. et al., "Attachment of Amino Groups to Polymer Surfaces by Radio-frequency Plasmas," J. Appl. Poly. Sci., 13, pp. 807-816 (1969).
Hollahan, J. R. et al., "Hydroxylation of Polymethal Siloxane Surfaces by Oxidizing Plasmas," J. Appl. Poly. Sci. 14, pp. 2499-2508 (1970).
Jacobs, H. A., "PGEI-Heparin Conjugate: Synthesis, Characterization and Application," Disseration submitted to the University of Utah (1987).
Kaetsu, Isao et al., "Studies on the Immobilization of Biofunctional Components by Radiation Polymerization and their Applications, Radia Phys. Chem., 27 vol. 27, pp. 245-263 (1986).
Ketteringham, John M. et al., "Permeable Surfaces," Annals New York Academy of Sciences, vol. 283, pp. 410-418 (1977).
Ketteringham, J. et al., "A High Permeability, Nonporous, Blood Compatible Membrane for Membrane Lungs: In Vivo and In Vitro Performance," Trans. Amer. Soc. Artif. Int. Organs, vol. XXI, pp. 224-233 (1975).
Kim, S. W. et al., "Nonthrombogenic Bioactive Surfaces," from Annals of the New York Academy of Sciences, vol. 516, pp. 116-130 (undated).
Kuzuya, Masayuki et al., "Mechanistic Insight into Immobilization and Release of Active Radical Species on a Novel Plasma-Driven Ultrathin Film," Chemistry Letters (one page), (1986).
Mori, Y. et al., "Permeability of Heparinized Hydrophilic Polymer (H-RSD): Application to Semipermeable Membrane for Microencapsulation of Activated Charcoal," J. Biomed. Mater. Res., vol. 16, pp. 17-30 (1982).
Pekala, Richard W. et al., "XPS Determination of Molecular Rearrangement at the Surface of a Cross-linked Polymer System," Journal of Colloid and Interface Science, vol. 101, No. 1, pp. 121-128 (Sep. 1984).
Pekala, R. W. et al., "Cross-linked Polyether/Polysiloxane Networks for Blood-Interfacing Applications," Biomaterials, vol. 7, pp. 372-378 (Sep. 1986).
Pekala, R. W. et al., "Fibrinogen Absorption and Platelet Adhesion at the Surface of Modified Polypropylene Glycol/Polysiloxane Networks," Biomaterials, vol. 7, pp. 379-385 (Sep. 1986).
Peric, D. et al., "Reverse Osmosis Characteristics of Composit
Berry Gaylord
Mortensen J. D.
Sanders Clifton G.
Solen Kenneth A.
Winters Suzanne
Cardiopulmonics, Inc.
Page Thurman K.
Phelan D. Gabrielle
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