Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Reexamination Certificate
2006-01-17
2006-01-17
Spector, Lorraine (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
C530S398000, C435S069400, C435S069700, C424S192100, C424S198100
Reexamination Certificate
active
06987172
ABSTRACT:
Glycosylated or nonglycosylated molecules of the formulain-line-formulae description="In-line Formulae" end="lead"?β1-(linker1)n1-β2-(linker2)n2-β3-(linker3)n3-α; (1)in-line-formulae description="In-line Formulae" end="tail"?in-line-formulae description="In-line Formulae" end="lead"?β1-(linker1)n1-β2-(linker2)n2-α-(linker3)n3-β3; (2)in-line-formulae description="In-line Formulae" end="tail"?in-line-formulae description="In-line Formulae" end="lead"?β1-(linker1)n1-α-(linker2)n2-β2-(linker3)n3-β3; (3)in-line-formulae description="In-line Formulae" end="tail"?andin-line-formulae description="In-line Formulae" end="lead"?α-(linker1)n1-β1-(linker2)n2-β2-(linker3)n3-β3 (4)in-line-formulae description="In-line Formulae" end="tail"?wherein α is the α subunit of a vertebrate glycoprotein hormone or a variant thereof;each β is independently a glycoprotein β subunit or a variant thereof,each “linker” is a hydrophilic, flexible spacer equivalent to a peptide containing 1–100 amino acid residues; andeach n is a 0 or 1;said compound optionally comprising one or more additional βx(linkerx)nxand/or one or more additional α subunits are useful in protocols to enhance fertility in humans and in animals.
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Boime Irving
Garcia-Campayo Vicenta
Morrison & Foerster / LLP
Spector Lorraine
Washington University in St. Louis
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