Multifunctional RNA having self-processing activity, the prepara

Details Multifunctional RNA having self-processing activity, the prepara Multifunctional RNA having self-processing activity, the prepara

1995-06-02

1998-11-10

Degen, Nancy

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

4353201, 435419, 514 44, 536 245, C12N 1563, C12N 504, C12N 1582, A61K 4800

Patent

active

058342656

ABSTRACT:
A multifunctional RNA having self-processing activity, the preparation thereof and the use thereof Host cells can be transformed so that they express ribozyme RNA and antisense RNA which are connected with each other via a spacer. The RNA molecules can, for example, be complementary to a certain viral RNA. Plants which have been transformed with genes coding for RNA of this type show a significantly improved resistance to viruses.

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Haseloff and Gerlach. Simple RNA enzymes with new and highly specific endoribonuclease activities. Nature. vol. 334:585-591, Aug. 18, 1988.
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