Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1994-09-29
1998-01-13
Fleisher, Mindy
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
4352404, 4352523, 514 44, 536 231, 536 241, 935 33, 935 34, 935 44, C12N 1500, C12N 500, A01N 4304, C07H 2102
Patent
active
057078408
ABSTRACT:
A multifunctional RNA having self-processing activity, the preparation thereof and the use thereof.
Host cells can be transformed so that they express ribozyme RNA and antisense RNA which are connected with each other via a spacer. The RNA molecules can, for example, be complementary to a certain viral RNA. Plants which have been transformed with genes coding for RNA of this type show a significantly improved resistance to viruses.
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Chuat & Galibert, Can Ribozymes Be Used to Regulate Procaryote Gene Expression?, Biochemical and Biophysical Research Communications 162(3) :1025-1029 (Aug. 15, 1989).
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Rossi and Sarver, RNA enzymes (ribozymes) as antiviral therapeutic agents, Tibtech, 8:179-183 (Jul. 1990).
Chang et al., Ribozyme-Mediated Site-Specific Cleavage of the HIV-1 Genome, Clinical Biotechnology, 2(1):23-31 (Jan./Feb. 1990).
Evans et al., The effects of ribozymes on gene expression in plants, Biochemical Society Transactions 20:344S (1992).
Rezaian et al., Plant Molecular Biology 11:463-471 (1988).
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Eckes Peter
Mullner Hubert
Schneider Rudolf
Uhlmann Eugen
Uijtewaal Bernadus
Fleisher Mindy
Hoechst Aktiengesellschaft
Weiss Bonnie D.
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