Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...
Patent
1993-10-05
1995-10-31
Nutter, Nathan M.
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Mixing of two or more solid polymers; mixing of solid...
525 542, 525 543, 528354, C08L 100
Patent
active
054629900
ABSTRACT:
Described herein is a multi-functional polymeric material for use in inhibiting adhesion and immune recognition between cells and cells, cells and tissues, and tissues and tissues. One component of the polymeric material adsorbs well to cells or tissue, and the other component of the polymeric material does not adsorb well to tissues. A water-soluble polymer that does not bear charge (polynonion) is used as the non-binding component, and a water soluble polymer that is positively charged at physiological pH (polycation) is used as the tissue binding component. When the bi-functional polymeric material contacts a tissue, the tissue-binding component binds and thus immobilizes the attached non-binding component, which will then extend generally away from the tissue surface and sterically block the attachment of other tissues. The method and compositions are useful in inhibiting formation of post-surgical adhesions, protecting damaged blood vessels from thrombosis and restenosis, and decreasing the extent of metastasis of attachment-dependent tumor cells.
REFERENCES:
patent: 2155658 (1936-01-01), Herrmann et al.
patent: 2917410 (1959-12-01), Vitalis
patent: 3068188 (1962-12-01), Beste et al.
patent: 3218283 (1965-11-01), Miller
patent: 3670045 (1972-06-01), Koleske et al.
patent: 3689531 (1972-09-01), Critchfield et al.
patent: 3760034 (1973-09-01), Critchfield et al.
patent: 3887699 (1975-06-01), Yolles
patent: 3925895 (1975-12-01), Kliment et al.
patent: 3939111 (1976-02-01), Schollenberger et al.
patent: 3960150 (1976-06-01), Hussain et al.
patent: 3981303 (1976-09-01), Higuchi et al.
patent: 3986510 (1976-10-01), Higuchi et al.
patent: 3993071 (1976-11-01), Higuchi et al.
patent: 4076800 (1978-02-01), Marsh et al.
patent: 4148871 (1979-04-01), Pitt et al.
patent: 4161948 (1979-07-01), Bichon
patent: 4193845 (1980-03-01), Kaetsu et al.
patent: 4194066 (1980-03-01), Kaetsu et al.
patent: 4195129 (1980-03-01), Fukui et al.
patent: 4226938 (1980-10-01), Yoshida et al.
patent: 4272617 (1981-06-01), Kaetsu et al.
patent: 4295762 (1981-10-01), Slovinsky
patent: 4298002 (1981-11-01), Ronel et al.
patent: 4310397 (1982-01-01), Kaetsu et al.
patent: 4352883 (1982-10-01), Lim
patent: 4376839 (1983-03-01), Malin
patent: 4391909 (1983-07-01), Lim
patent: 4408023 (1983-10-01), Gould et al.
patent: 4409331 (1983-10-01), Lim
patent: 4411754 (1983-10-01), Kaetsu et al.
patent: 4434150 (1984-02-01), Azad et al.
patent: 4450150 (1984-05-01), Sidman
patent: 4452973 (1984-06-01), Casey et al.
patent: 4511478 (1985-04-01), Nowinski et al.
patent: 4512910 (1985-04-01), Schmidle
patent: 4526938 (1985-07-01), Churchill et al.
patent: 4533445 (1985-08-01), Orio
patent: 4563489 (1986-01-01), Urist
patent: 4605622 (1986-08-01), Hasegawa et al.
patent: 4631188 (1986-12-01), Stoy et al.
patent: 4636552 (1987-01-01), Gay et al.
patent: 4637931 (1987-01-01), Schmitz
patent: 4650488 (1987-05-01), Bays et al.
patent: 4655777 (1987-04-01), Dunn et al.
patent: 4663286 (1987-05-01), Tsang et al.
patent: 4689293 (1987-08-01), Goosen et al.
patent: 4716203 (1987-12-01), Casey et al.
patent: 4741337 (1988-05-01), Smith et al.
patent: 4744365 (1988-05-01), Kaplan et al.
patent: 4744933 (1988-05-01), Rha et al.
patent: 4745160 (1988-05-01), Churchill et al.
patent: 4749620 (1988-06-01), Rha et al.
patent: 4767627 (1988-08-01), Caldwell et al.
patent: 4774178 (1988-09-01), Egerer et al.
patent: 4804691 (1989-02-01), English et al.
patent: 4806355 (1989-02-01), Goosen et al.
patent: 4826945 (1989-05-01), Cohn et al.
patent: 4857602 (1989-08-01), Casey et al.
patent: 4888413 (1989-12-01), Domb
patent: 4889722 (1989-12-01), Sheffield et al.
patent: 4891263 (1990-01-01), Kotliar et al.
patent: 4913903 (1990-04-01), Sudmann et al.
patent: 4916193 (1990-04-01), Tang et al.
patent: 4920203 (1990-04-01), Tang et al.
patent: 4921934 (1990-05-01), Bixler et al.
patent: 4925677 (1990-05-01), Feijen
patent: 4933430 (1990-06-01), Kessler et al.
patent: 4938763 (1990-07-01), Dunn et al.
patent: 4942035 (1990-07-01), Churchill et al.
patent: 4950596 (1990-08-01), Cheng et al.
patent: 4957744 (1990-09-01), della Valle et al.
patent: 4983689 (1991-01-01), Yu et al.
patent: 4994277 (1991-02-01), Higham et al.
patent: 4999417 (1991-03-01), Domb et al.
patent: 5049138 (1991-09-01), Chevalier et al.
patent: 5077049 (1991-12-01), Dunn et al.
patent: 5108755 (1992-04-01), Daniels et al.
patent: 5126141 (1992-06-01), Henry
patent: 5129889 (1992-07-01), Hahn et al.
patent: 5135751 (1992-08-01), Henry et al.
patent: 5153002 (1992-10-01), McMullen
patent: 5185408 (1993-02-01), Tang et al.
patent: 5219564 (1993-06-01), Zalipsky et al.
patent: 5258034 (1993-11-01), Furlong et al.
patent: 5270400 (1993-12-01), Spinu
patent: 5278201 (1994-01-01), Dunn et al.
patent: 5278202 (1994-01-01), Dunn et al.
patent: 5334640 (1994-08-01), Desai et al.
Anzinger, Hermann, et al., "Peptide mit ungewohnlichen Seitenketten, Synthese und Konformation von Polyethylenglykol--Polylysin-Blocken mit mesogenen Seitengruppen," Makromol. Chem. Rapid Comm. 2, 637-643 (1981).
Bader, Huber, et al., "Watersoluble Polymers in Medicine," Die Ang. Makromol. Chem. 123/4:457-485 (1984).
Bogdanov, Alexei A., et al., "A New Macromolecule as a Contrast Agent for MR Angiography: Preparation, Properties, and Animal Studies," Radiology 187, 701-706 (1993).
Ertel, Sylvie, et al., "Copolymers of Amino Acids and Poly(ethylene Glycol): A New Family of Functionalized Drug-Carriers," Proc. Amer. Chem. Soc. Div. Poly. Mater. 486-487 (1992).
Pratten, Margaret K., et al., "Micelle-forming block copolymers: Pinocytosis by macrophages and interaction with model membranes," Makromol. Chem. 186, 725-733 (1985).
Abraham, K. M. and Alamgir, M., "Dimensionally Stable MEEP-Based Polymer Electrolytes and Solid-State Lithium Batteries," Chem. Mater., 3:339-348 (1991).
Abuchowski, et al., "Alteration of Immunological Properties of Bovine Serum Albumin by Covalent Attachment of Polyethylene Glycol," J. Biol. Chem., 252(11):3578-3581 (1977).
Altman, J. J., et al., "Long-Term Plasma Glucose Normalization in Experimental Diabetic Rats With Microencapsulated Implants of Benign Human Insulinomas," Diabetes 35:625-633.
Amudenwari, et al., "Short-term biocompatibility studies of hydrogel-grafted collagen copolymers," J. Biomed. Materials Res., 20:1103-1109 (1986).
Andrade and Hlady, "Protein Adsorption and Materials Biocompatibility: A Tutorial Review and Suggested Hypothesis," Advances in Polymer Science, published by Springer-Verlag Berlin Heidelberg, pp. 1-63 (1986).
Brosse, J. C., et al., "Polymerisation de monomeres organiques dans des plasmas froids-l, Polymerisation de monomeres acryliques deposes en couches minces," Eur. Polym. J., 19:381-385 (1983).
Buck, "Cell Surface Receptors for Extracellular Matrix Molecules," Ann. Rev. Cell Bio., 3:179-205 (1987).
Cerrai, P., et al., "Polyether-polyester block copolymers by non-catalysed polymerization of e-caprolactone with poly(ethylene glycol)," Polymer, 30:338-343 (1989).
Chiang, W-Y, and Chan, S-C, "Preparation and Properties of UV-Autocurable BTDA-Based Polyester Multiacrylates. I. Effects of Acrylic Functionality and Polyol Molecular Weight," J. App. Pol. Sci., 41:2971-2985 (1990).
Chun, et al., "Studies on Microbial Transformations XIX, Use of Immobilized Cells of Streptomyces Roseochromogenes for the 16 .alpha.-Hydroxylation of Dehydroepiandrosterone" J. Appl. Microbiol., 27:505-509 (1981).
Cohn and Younes, "Biodegradable PEO/PLA block copolymer," J. Biomed. Materials Research, 22:993-1009 (1988).
Coleman, et al., "Blood-materials interactions: the Minimum Interfacial free energy and the optimum polar/apolar ratio hypothesis", J. Biomed. Materials Res., 16:381-398 (1982).
Crooks, Colin A., et al., "Microencapsulation of mammalian cells in a HEMA-MMA copolymer: Effects on capsule morphology and permeability," Journal of Biomedical Materials Research 24:1241-1262 (1990).
Darguy and Reach, "Immunoisolation of pancreatic a cells by microencapsulation--an in vitro study," Diabetologia, 28:776-780 (1985).
Desai, et al., "The short-term blood biocompatibility of
Chowdhury Sanghamitra
Drumheller Paul D.
Elbert Donald
Hill-West Jennifer L.
Hubbell Jeffrey A.
Board of Regents , The University of Texas System
Nutter Nathan M.
Pabst Patrea L.
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