Multifunctional M-CSF proteins and genes encoding therefor

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 697, 536 234, C07K 1452, C12N 1519

Patent

active

060229535

ABSTRACT:
Multifunctional proteins having M-CSF activity and at least one other bioactivity not found together in a single naturally occuring molecule are described. These multifunctional M-CSF proteins can be produced by the expression of fused genes which are also described. These multifunctional M-CSF proteins have increased therapeutic potential.

REFERENCES:
patent: 4468382 (1984-08-01), Bacha et al.
patent: 4518584 (1985-05-01), Mark et al.
patent: 4545985 (1985-10-01), Pastan et al.
patent: 4675382 (1987-06-01), Murphy
patent: 4703008 (1987-10-01), Lin
patent: 4738927 (1988-04-01), Taniguchi et al.
patent: 4752585 (1988-06-01), Koths et al.
patent: 4758428 (1988-07-01), Mark et al.
patent: 4762791 (1988-08-01), Goeddel et al.
patent: 4762914 (1988-08-01), Auron et al.
patent: 4778879 (1988-10-01), Mertelsmann et al.
patent: 4801686 (1989-01-01), Kronheim
patent: 4808611 (1989-02-01), Cosman
patent: 4810643 (1989-03-01), Souza
Tonouchi et al., 1988, J. Biochem., 104:30-34.
Sideras et al., 1988, Immunological Reviews, 102:189-212.
Kaushansky et al., 1986, PNAS (USA),83:3101-3105.
Feng, G-S. et al., 1988, Science 241:1501-1503.
Kelley, V.E. et al., 1988, Proc. Natl. Acad. Sci. USA 85:3980-3984.
Ralph, P. et al., 1986, Blood 68:633-639.
Pirker, R. et al. 1985, J. Clin. Invest. 76:1261-1267.
Veronese, F. et al., 1985, Applied Biochem & Biotech 11:141-152.
Ralph, P. et al., in The Year in Immunology 1988, Cruse et al., eds., Basel, Karger, 1989, vol. 5, pp. 103-125.
Ralph, P. "Colony Stimulating Factors", in Human Monocytes, Asherson et al. eds., Academic Press, 1989, pp. 227-246.
Metcalf, D., 1970, J. Cell. Physiol. 76:89-100.
Das, S.K. et al., 1981, Blood 58:630-641.
Das, S.K. et al., 1982, J. Biol. Chem. 257:13679-12681.
Stanley, E.R. et al., 1977, J. Biol. Chem. 252:4305-4312.
Halenbeck, R. et al., 1989, Bio/Technology, in press.
Wong, G.G. et al., 1987, Science 235:1504-1508.
Kawasaki, E.S. et al., 1985, Science 230:291-296.
Ladner, M.B. et al., 1987, EMBO J. 6:2693-2698.
Cerretti, D.P. et al., 1988, Molecular Immunol. 25:761-770.
Takahashi, M. et al., 1988, Bioch. Biophys. Res. Comm. 152:1401-1409.
Taniguchi, T. et al., 1983, Nature 302:305-310.
Devos et al., 1983, Nucleic Acids Res. 11:4307-4323.
Cerretti et al., 1986, Proc. Natl. Acad. Sci. USA 83:3223-3227.
Chemical Abstracts, 1987, 106:(21):170236f (abstract of Japanese Patent Publication No. 61/225199).
Gray, P.W. et al., 1983, Proc. Natl. Acad. Sci. USA 80:5842-5864.
March, C.J. et al., 1985, Nature 315:641-646.
Auron, P.E. et al., 1984, Proc. Natl. Acad. Sci. USA 81:7907-7911.
Hirano, T. et al., 1986, Nature 324:73-76.
Wong, G.G. et al., 1988, Immunol. Today 9:137-139.
Katre, N. et al., 1987, Proc. Natl. Acad. Sci. USA 84:1487-1491.
Rosenberg, S.A., et al., 1984, Science 223:1412-1415.
Wang, A. et al., 1984, Science 224:1431-1433.
Doyle, M. et al., J. Biol. Resp. Modifiers 4:96-109.
Rosenberg, S.A. et al., J. Exp. Med. 161:1169-1188.
Rosenberg, S.A. et al., 1986, Science 233:1318-1321.
Chong, K.T. et al. 1988, FASEB J. 2(5):1474.
Lee, et al., 1987, J. Immunol. 138:3019-3022.
Goronzy, J. et al., 1989, J. Immunol. 142:1134-1138.
Merigan et al., 1988, J. Immunol. 140:294-299.
Moore, M.A.S. et al., in Recent Advances in Leukemia and Lymphoma, Alan R. Liss, Inc., pp. 445-456.
Mochizuki, D.Y. et al., Proc. Natl. Acad. Sci. USA 84:5267-5271.
Zsebo, K.M. et al., 1988, Blood 71:962-968.
Bartelmez, S.H. et al., Exp Hematol. 17:240-245.
Bot, F.J. et al., 1989, Blood 73:435-437.
Nakoinz I. et al., 1988, Cell. Immunol. 116:331-340.
Sampson-Johannes et al., 1988, J. Immunol. 114:3680-3686.
Karbassi, A. et al., 1987, J. Immunol. 139:417-421.
Streuli, M. et al, 1981, Proc. Natl. Acad. Sci. USA 78:2848-2852.
Weck, P.K. et al., 1981, Nucleic Acids Res. 9:6153-6166.
Chaudhary, V.K. et al., 1987, Proc. Natl. Acad. Sci. USA 84:1-5.
Siegall, C.B. et al., 1988, Proc. Natl. Acad. Sci. USA 85:9738-9742.
Bailon, P. et al., 1988, Bio/Technol. (Nov.):1326-1329.
Lorberboun-Galski et al., 1988, Proc. Natl. Acad. Sci. USA 85:1922-1926.
Vallette, F. et al., 1989, Nucl. Acid. Res. 17(2):723-733.
Wong et al. Science 235:1504-1508, 1987.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Multifunctional M-CSF proteins and genes encoding therefor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Multifunctional M-CSF proteins and genes encoding therefor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Multifunctional M-CSF proteins and genes encoding therefor will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1682157

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.