Multifunctional linking reagents for synthesis of branched oligo

Details Multifunctional linking reagents for synthesis of branched oligo Multifunctional linking reagents for synthesis of branched oligo

1997-01-08

1999-06-29

Houtteman, Scott W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

544 83, C12Q 168, C07D41300

Patent

active

059167505

ABSTRACT:
Reagents capable of forming branched oligomers with monomeric units are disclosed, together with oligomers incorporating such reagents, kits containing such reagents and methods for use of such reagents in forming oligomers with monomeric units. The present reagents can advantageously be used to introduce multiple labels or reporter molecules onto oligomers such as oligonucleotides and oligopeptides. In particular, non-nucleosidic phosphoramidites based on 1,3,5-tris(2-hydroxyethyl)cyanuric acid are disclosed. Multiply-labeled, branched DNA oligomer probes constructed using these phosphoramidite reagents showed increased signal intensity relative to singly-labeled oligomer probes.

REFERENCES:
patent: 3574520 (1971-04-01), Aldrich
patent: 5571677 (1996-11-01), Gryaznov

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