Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Reexamination Certificate
2007-12-11
2007-12-11
Jones, Dameron L. (Department: 1618)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
C424S001110, C424S001650, C424S001810, C424S009300, C424S009362, C424S009400
Reexamination Certificate
active
10947112
ABSTRACT:
A multifunctional cross-bridged tetraaza macrocyclic compound has at least one side arm that comprises a moiety that is capable of forming a bond with another molecule, which has a targeting moiety that directs the compound to a site a marker substance. The compound is chelated to a medically active material that generates a signal for diagnostic imaging or produces a therapeutic effect at the site of the marker substance. A method for detecting, diagnosing, and/or treating a disease that produces the marker substance uses a conjugate comprising the multifunctional cross-bridged tetraaza macrocyclic compound.
REFERENCES:
patent: 4361544 (1982-11-01), Goldenberg
patent: 4474893 (1984-10-01), Reading
patent: 4479895 (1984-10-01), Auditore-Hargreaves
patent: 4946778 (1990-08-01), Ladner et al.
patent: 6395474 (2002-05-01), Buchardt et al.
patent: 6451968 (2002-09-01), Egholm et al.
patent: 6489472 (2002-12-01), Giandomenico et al.
patent: 6555681 (2003-04-01), Hiler, II et al.
patent: 6656450 (2003-12-01), Hubin et al.
Golub et al., Science, vol. 286, Oct. 15, 1999, pp. 531-537.
X. Sun et al., “Radiolabeling and In Vivo Behavior of Copper-64-Labeled Crosss-Bridged Cyclam Ligands,” J. Med. Chem., vol. 45, pp. 469-477 (2002).
E.H. Wong et al., J. Am. Chem. Soc., vol. 122, pp. 10561-10572 (2000).
W.J. Krupper et al., J. Org. Chem., vol. 58, pp. 3869-3876 (1993).
Milstein et al., Immunology Today, vol. 5, (1984), 299-304.
L.L. Chappell et al., “Improved Synthesis of the Bifunctional Chelating Agent 1,4,7,10-Tetraaza-N-(1-carboxy-3-(4-nitrophenyl)-N′,N″,N″′-tris(acetic acid)cyclododecane,” Bioorg. Med. Chem., vol. 7, No. 11, 2313-20 (1999).
Bresnahan Maureen
General Electric Company
Jones Dameron L.
Testa Jean K.
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