Multidrug resistance protein

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435 697, 4352402, 4353201, 536 235, 536 245, C12N 1512, C12N 1663, C12N 510, C12N 516

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054895197

ABSTRACT:
A novel protein associated with multidrug resistance in living cells and capable of conferring multidrug resistance on a cell is disclosed and nucleic acids encoding the novel isoforms are disclosed. Transformant cell lines which express the nucleic acid encoding the novel protein are also disclosed. Further, diagnostic and treatment methods using the novel protein, nucleic acids and cell lines are also disclosed.

REFERENCES:
patent: 4740461 (1988-04-01), Kaufman
patent: 4912039 (1990-03-01), Riordan
patent: 4965199 (1990-10-01), Capen et al.
patent: 5166059 (1992-11-01), Pastan et al.
patent: 5198344 (1993-03-01), Croop et al.
patent: 5206352 (1993-04-01), Roninson et al.
patent: 5266488 (1993-11-01), Ordahl et al.
Cole, S. P. C. et al. (1993) "MRP: A Novel ATP-Binding Cassette Transporter Gene Isolated From a Multidrug Resistant Small Cell Lung Cancer Cell Line" Third International IASLC Workshop on Lung Tumor and Differentiation Antigens (Abstract).
Slovak, M. L. et al. (1993) "Localization of a Novel Multidrug Resistance-Associated Gene in the HT1080/DR4 and H69AR Human Tumor Cell Lines" Cancer Res. 53:3221-3225.
Cole, S. P. C. et al. (1993) "A Novel ATP-Binding Cassette Transport Gene Overexpressed in Multidrug-Resistant Human Lung Tumor Cells" Proc. Am. Assoc. Cancer Res. 34:579 (Abstract).
Barrand, M. A. et al. (1992) "Chemosensitisation and Drug Accumulation Effects of Cyclosporin A, PSC-833 and Verapamil in Human MDR Large Cell Lung Cancer Cells Expressing a 190k Membrane Protein Distinct from P-Glycoprotein" Eur. J. Cancer 29A(3):408-415.
Krishnamachary, N. et al. (1993) "The MRP Gene Associated with a Non-P-Glycoprotein Multidrug Resistance Encodes a 190-kDa Membrane Bound Glycoprotein" Cancer Res. 53:3658-3661.
Cole, S. P. C. et al. (1992) "Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line" Science 258:1650-1654.
Cole, S. P. C. et al. (1993) "Multidrug Resistance-Associated Protein: Sequence Correction" Science 260:879.
Higgins, C. F. (1992) "ABC Transporters: From Microorganisms to Man" Annu. Rev. Cell Biol. 8:67-113.
DelaFlor--Weiss, E. et al. (1992) "Transfer and Expression of the Human Multidrug Resistance Gene in Mouse Erythroleukemia Cells" Blood 80(12):3106-3111.
Podda, S. et al. (1992) "Transfer and Expression of the Human Multiple Drug Resistance Gene into Live Mice" Proc. Natl. Acad. Sci. USA 89;9676-9680.
Cole, S. P. C. (1991) "The 1991 Merck Frosst Award. Multidrug Resistance in Small Cell Lung Cancer" Can. J. Physiol. Pharmacol. 70:313-329.
Hyde, S. C. et al. (1990) "Structure Model of ATP-Binding Proteins Associated With Cystic Fibrosis, Multidrug Resistance and Bacterial Transport" (1990) Nature 346:362-365.
Marquardt, D. et al. (1990) "Mechanisms of Multidrug Resistance in HL60 Cells: Detection of Resistance-Associated Proteins with Antibodies Against Synthetic Peptides That Correspond to the Deduced Sequence of P-Glycoprotein" Cancer Res. 50:1426-1430.
Rivoltini, L. et al. (1990) "Modulation of Multidrug Resistance By Verapamil or mdr1 Anti-Sense Oligodeoxynucleotide Does Not Change The High Susceptibility to Lymphokine-Activated Killers in Mdr-Resistant Human Carcinoma (LoVo) Line" Int. J. Cancer 46:727-732.
Quellette, M. et al. (1990) "The Amplified H Circle of Methotrexate-Resistant Leishmania Tarentolae Contains a Novel P-Glycoprotein Gene" EMBO J. 9:1027-1033.
Cole, S. P. C. (1990) "Patterns of Cross-Resistance in a Multidrug-Resistant Small-Cell Lung Carcinoma Cell Line" Cancer Chemother. Pharmacol. 26:250-256.
Cole, S. P. C. et al. (1989) "Effect of Calcim Antagonists on the Chemosensitivity of Two Multidrug-Resistant Human Tumor Cell Lines Which do not Overexpress P-Glycoprotein" Br. J. Cancer 59:42-46.
Mirski, S. E. L. et al. (1987) "Multidrug Resistance in a Human Small Cell Lung Cancer Cell Line Selected in Adriamycin" Cancer. Res. 47:2594-2598.
Ueda, K. et al. (1986) "The mdr1 Gene, Responsible For Multidrug-Resistance, Codes For P-Glycoprotein" Biochem. and Biophys. Res. Comm. 141(3):956-962.
Chen, C-J. et al. (1986) "Internal Duplication and Homology with Bacterial Transport Proteins in the mdr1 (P-Glycoprotein) Gene from Multidrug-Resistant Human Cells" Cell 47:381-389.
Roninson, I. B. et al. (1986) "Isolation of Human mdr DNA Sequences Amplified in Multidrug-Resistant KB Carcinoma Cells" Proc. Natl. Acad. Sci. USA 83:4538-4542.
Gros, P. et al. (1986) "Isolation and Characterization of DNA Sequences Amplified in Multidrug-Resistant Hamster Cells" Proc. Natl. Acad. Sci. USA 83:337-341.
Fojo, A. T. et al. (1985) "Amplification of DNA Sequences in Human Multidrug-Resistant KB Carcinoma Cells" Proc. Natl. Acad. Scient. USA 82:7661-7665.
Riordan, J. R. et al. (1985) "Amplification of P-Glycoprotein Genes in Multidrug-Resistant Mammalian Cell Lines" Nature 316:817-819.
Roninson, I. B. et al. (1984) "Amplification of Specific DNA Sequences Correlates With Multi-Drug Resistance in Chinese Hamster Cells" Nature 309:626-628.
Garnier et al. 1989. Jn: Fasman, G. (ed.), Prediction of Protein Structure and the Principles of Protein Conformation, Plenum Press, N.Y. pp. 417-465.
DIALOG abstract accessia No. 90359500 of file 155, Jaroszewshi et al. 1990. Cancer Commun. 2(8):287-294.
Pongon, S. 1987. Methods in Enzymology 154:450-473.
Uhlmann et al. 1990. Chemical Reviews, 90(4):544-584.

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