Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-01-24
1995-04-11
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31385
Patent
active
054058660
ABSTRACT:
Compounds of the formula. ##STR1## wherein R is a residue of the formula ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, X, Y and Z are as described, with the exception of rac-N-(3,4-dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)-.beta.,N-dimethyl-m -dithiane-2-propanamine, as well as their acid addition salts, in particular for use in eliminating cytostatic resistance in tumor treatment and chloroquine resistance in malaria.
REFERENCES:
patent: 4003914 (1977-01-01), Ramuz
patent: 4073797 (1978-02-01), Ramuz
patent: 4127588 (1978-11-01), Ramuz
Tsuruo et al., "Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil", Cancer Res. 41:1967-1972 (1981).
Ramuz et al, Eur. J. Med. Chem., vol. 24 (1989) pp. 493-496.
Eliason James F.
Kaufman-Schmid, deceased Franz A.
Ramuz Henri
Epstein William H.
Gould George M.
Hoffmann-La Roche Inc.
Raymond Richard L.
Roseman Catherine R.
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