Multidrug multiligand conjugates for targeted drug delivery

Details Multidrug multiligand conjugates for targeted drug delivery Multidrug multiligand conjugates for targeted drug delivery

2007-12-25

2007-12-25

Chan, Christina (Department: 1644)

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

C424S169100, C424S181100, C424S193100, C424S194100, C424S195110, C530S329000, C530S391100, C514S015800, C514S016700

Reexamination Certificate

active

10281840

ABSTRACT:
Described is a multi drug multiligand conjugate for targeted drug delivery. The MDML conjugate contains a plurality of tripartite molecules linked to a central scaffold moiety, with each tripartite molecule comprising a targeting molecule, a therapeutic agent and a scaffold binding element. The MDML conjugate allows for more efficient delivery of therapeutic agents to the cells resulting in enhanced therapeutic efficiency. A model MDL conjugate is disclosed as well as method for the synthesis of the model conjugate.

REFERENCES:
patent: 4863713 (1989-09-01), Goodwin et al.
patent: 5976535 (1999-11-01), Fritzberg et al.
patent: 6191290 (2001-02-01), Safavy
patent: 6200546 (2001-03-01), Hoffman
patent: 6287536 (2001-09-01), Reno et al.
patent: 6436386 (2002-08-01), Roberts et al.
patent: WO 98/47524 (1998-10-01), None
patent: WO 00/78359 (2000-12-01), None
Deguchi et al, Bioconjugate Chem 10: 32-37, Jan.-Feb. 1999.
Stryer et al, in Biochemistry, Third edition, W H Freeman Company, New York, pp. 31-33, 1998.
Ngo et al., 1994, The Protein Folding Problem and Tertiary Structure Prediction, pp. 491-495.
Livnah et al, FEBS 328(1-2): 165-168, Aug. 1993.
Pardridge et al, Pharmaceutical Research 15(4): 576-582, 1998.
Nathan et al, Bioconjug chem. 4(1): 54-62, Jan.-Feb. 1993.
Safavy, A., et al., Paclitaxel Derivatives for Targeted Therapy of Cancer; Toward the Development of Smart Taxanes, Journal of Medicine Chemistry. Nov. 1999, vol. 42, No. 23 pp. 4919-4924.
Safavy, A., et al. Synthesis of Bombesin Analogues for Radiolabeling with Rhenium-188. Cancer. Dec. 1997, vol. 18, No. 12, pp. 2354-2359.
Safavy, A., et al. Synthesis, Cytotoxicity Evaluation, and Biodistribution Studies of a Novel Paclitasxes-MAb C225 Conjugate. Cancer Biotherapy and Radiopharmaceuticals. 2000.

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