Multidrop tree branching functional polyethylene glycol,...

Details Multidrop tree branching functional polyethylene glycol,... Multidrop tree branching functional polyethylene glycol,...

2006-12-05

2006-12-05

Truong, Duc (Department: 1711)

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

From organic oxygen-containing reactant

C528S328000, C528S271000, C528S480000, C546S300000, C548S545000, C562S451000, C564S504000

Reexamination Certificate

active

07144978

ABSTRACT:
Multi-armed functional polyethylene glycol polymers with active terminal groups may be used in conjugation with small molecule pharmaceuticals, proteins and peptides to enhance half-life and bioavailability of the drug and improve solubility, stability and immunological competence.

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Bailon et al, Polyethylene glycol conjugates of alpha-interferons, 1997, F. Hoffmann-La Roche A, Switz., Chem Abstact 128: 47304.
Harris et al, Multi-armed, —and molecules, 1996, Shearwater Polymers, Inc., Chem Abstract 125: 204527.
Monfardini et al, A branched monomethoxy poly(ethylene glycol) for protein modification, 1995, Bioconjugate Chemistry 6 (1), 62-9, Chem Abstract 122: 75898.

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