Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Reexamination Certificate
2007-03-06
2007-03-06
Jones, Dameron L. (Department: 1618)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
C424S009300, C534S014000, C534S015000, C534S010000, C540S450000
Reexamination Certificate
active
10484111
ABSTRACT:
Compounds of general formula (I): in which: R1is hydrogen, C1–C20alkyl, C3–C10cycloalkyl, C4–C20cycloalkylalkyl, aryl, arylalkyl, or two R1, taken together, form a straight or cyclic C2–C10alkylene group or an ortho disubstituted arylene; R2is hydrogen, C1–C20alkyl, C3–C10cycloalkyl, C4–C20cycloalkylalkyl, aryl or aryl alkyl optionally substituted with functional groups which allow conjugation with a suitable molecule able to interact with physiological systems; R3, R4and R5are hydrogen, C1–C20alkyl, C3–C10cycloalkyl, C4–C20cycloalkylalkyl, aryl, arylalkyl; and their chelates with bi-trivalent ions of the metal elements having atomic number ranging between 20 and 31, 39, 42, 43, 44, 49, and between 57 and 83, and radioisotopes chosen among203Pb67Ga68Ga72As111In113In90Y97Ru62Cu64Cu52Fe52mMn140La175Yb153Sm166Ho149Pm177Lu142Pr159Gd212Bi47Sc149Pm67Cu,111Ag,199Au,161Tb and51Cr as well as the salts thereof with physiologically compatible bases or acids
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Aime Silvio
Calabi Luisella
Cavallotti Camilla
Giovenzana Giovanni Battista
Palmisano Giovanni
Bracco Imaging S.p.A.
Jones Dameron L.
Kramer Levin Naftalis & Frankel LLP
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