Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-10-07
1996-02-27
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546133, 546137, A61K 31435, C07D45302
Patent
active
054949181
ABSTRACT:
This invention relates to polycyclic compounds containing two mono- and/or bicyclic rings and a basic tertiary amino group capable of forming an ammonium ion at biological pH and which reduces levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
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Poulter, C. D., et al., "Squalene Synthetase. Inhibition by Ammonium Analogues of Carbocationic Intermediates in the Conversion of Presqualene Diphosphate to Squalene," J. Am. Chem. Soc., vol. III, No. 10, pp. 3734-3739 (1989).
Biller, S. A., et al., "Isoprenoid (Phosphenylmethyl)-phosphonates as Inhibitors of Squalene Synthetase," J. Med. Chem., vol. 31, No. 10, pp. 1869-1871 (1988).
Amin Dilip
Morris Robert L.
Neuenschwander Kent
Scotese Anthony C.
Huang Evelyn
Ivy C. Warren
Nicholson James A.
Parker III Raymond S.
Rhone-Poulenc Rorer Pharmaceuticals Inc.
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