Multicyclic sulfonamide compounds as inhibitors of histone...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C549S362000, C549S462000, C548S484000, C548S302700, C546S139000, C546S134000, C546S246000, C544S159000, C544S339000, C544S381000, C514S464000, C514S396000, C514S252200, C514S315000

Reexamination Certificate

active

07470722

ABSTRACT:
Disclosed herein are carbonyl compounds of Formula I as described herein.Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.

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Joseph E. Payne; Inhibitors of Histone Deacetylase for the Treatment of Disease; U.S. Appl. No. 11/608,736, filed Dec. 8, 2006 (not yet published); Kalypsys, Inc.

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