Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Reexamination Certificate
2004-03-09
2010-02-23
Graser, Jennifer E (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
C424S192100, C424S193100, C424S197110, C536S123100
Reexamination Certificate
active
07666438
ABSTRACT:
Multicomponent vaccines are provided which aid in the prevention and treatment of staphylococcal infections and which include certain selected combinations of bacterial binding proteins or fragments thereof, or antibodies to those proteins or fragments. By careful selection of the proteins, fragments, or antibodies, a vaccine is provided that imparts protection against a broad spectrum ofStaphylococcusand other bacterial strains and against proteins that are expressed at different stages of the logarithmic growth curve. In one embodiment of the invention, a composition is provided that includes a fibrinogen binding domain of a fibrinogen binding protein and a bacterial component such as ca capsular polysaccharide, and both active and passive vaccines based on these components are also provided, along with methods of treating infection using these compositions and vaccines.
REFERENCES:
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patent: 6288214 (2001-09-01), Hook et al.
Fattom et al (Infect. Immun. Jul. 1990. 58(7): 2367-2374.
Fattom et al (Infect. Immun. May 1996, 64(5): 1659-1665).
Rudinger et al, in “Peptide Hormones”, edited by Parsons, J.A., University Park Press, Jun. 1976, p. 6).
Lee, “The prospects for developing a vaccine againstStaphylococcus aureus”, Trends in Microbiology, vol. 4, No. 4, pp. 162-166 (Apr. 1996).
Smeltzer et al “Prevalence and Chromosomal Map Location ofStaphylococcus aureusAdhesion Genes” 1997, pp. 249-259, Gene—An International Journal on Genes and Genomes.
Foster Timothy J.
Hook Magnus
Patti Joseph M.
Graser Jennifer E
Inhibitex, Inc.
Schulman B. Aaron
Stites & Harbison PLLC
The Provost Fellows and Scholars of the College of the Holy and
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