Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1998-03-11
2000-08-01
Davenport, Avis M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
427 21, 427 214, A01N 4304, A61J 300, B01J 1300, A61L 5103
Patent
active
060967269
ABSTRACT:
Compositions and methods for use with substrates which are useful in the sustained delivery of bioeffecting agents are described. The compositions of the invention include a multicomponent complex which attaches a bioeffecting agent to a substrate with an anchor provided by a linker compound which also forms a cleavable linkage so that the bioeffecting agent's release into the area surrounding the substrate occurs in a sustained manner over an extended period of time. The methods of the invention involve providing a bioeffecting composition on the surface of a substrate so that a bioeffecting agent may be released in a sustained manner over time.
REFERENCES:
patent: 5702754 (1997-12-01), Zhong
Song, Cunxian et al., "Functional poly(.epsilon.-caprolactone)/polyether block copolymers as hemocompatible matrix for protein release", Proc. Int. Symp. Controlled Release Bioact. Mater. (1997), 24.sup.th, 465-476, XP002111230 (Figure 1).
Van Delden, C.J. et al., "Heparinization of gas plasma-modified polystyrene surfaces and the interactions of these surfaces with proteins studied with surface plasmon resonance", Biomaterials (1997), 18(12), 845-852, XP002111231.
Database WPI, Section Ch, Week 7932, Derwent Publications Ltd., London, GB; Class A23, AN 79-58650B, XP002111232 & JP 54 079997 A (Unitika Ltd.), Jun. 26, 1979, Abstract.
Database WPI, Section Ch, Week 7715, Derwent Publications Ltd., London, GB; Class A23, AN 77-26254Y, XP002111233 & JP 52 028596 A (Unitika Ltd.), Mar. 3, 1977, Abstract.
Davenport Avis M.
Surface Solutions Laboratories Incorporated
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